Synthesis of chiral dendrimers with a hydrocarbon backbone and application to the catalytic enantioselective addition of dialkylzincs to aldehydes

Itaru Sato, Takanori Shibata, Koji Ohtake, Ryo Kodaka, Yutaka Hirokawa, Nobuaki Shirai, Kenso Soai

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Abstract

Chiral dendrimers with three or six β-amino alcohols on hyperbranched hydrocarbon chain-ends were synthesized. These macromolecules can act as chiral catalysts for the enantioselective addition of dialkylzincs to aldehydes. The corresponding secondary alcohols are obtained in high enantiomeric excess (up to 86% e.e.). (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)3123-3126
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number17
DOIs
Publication statusPublished - 2000 Apr 22
Externally publishedYes

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Keywords

  • Asymmetric synthesis
  • Catalysts
  • Dendrimers
  • Enantioselection

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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