Synthesis of cobalt ferrite nanoparticles using spermine and their effect on death in human breast cancer cells under an alternating magnetic field

Shofu Matsuda, Takuya Nakanishi, Kisako Kaneko, Tetsuya Osaka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To compare heat generation under an AC magnetic field for inducing cancer cell death, CoFe2O4 and Fe3O4 nanoparticles with a diameter of ∼10 nm were synthesized by hydrolysis in an aqueous solution containing the metal chlorides iron(III) chloride and cobalt(II) or iron(II) chloride, with spermine or N,N'-bis(3-aminopropyl)butane-1,4-diamine, as a base and a protective reagent. Both CoFe2O4 and Fe3O4 nanoparticles were incorporated into human breast cancer MCF-7 cells; the nanoparticles exhibited little toxicity on the cells. When the cells containing nanoparticles were subjected to an AC magnetic field, MCF-7 cell death was induced by heat generated from ∼10-nm CoFe2O4 nanoparticles but not from ∼10-nm Fe3O4 nanoparticles. An increase in coercivity derived from the substitution of Fe2+ with Co2+ facilitated the ability of the nanoparticles to induce cell death in human breast cancer cells under an AC magnetic field.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalElectrochimica Acta
Volume183
DOIs
Publication statusPublished - 2015 Nov 20

Fingerprint

Spermine
Ferrite
Cobalt
Cells
Magnetic fields
Nanoparticles
Cell death
Chlorides
Iron
Diamines
Heat generation
Butane
cobalt ferrite
Coercive force
Toxicity
Hydrolysis
Substitution reactions
Metals

Keywords

  • Cellular uptake
  • CoFeO nanoparticles
  • FeO nanoparticles
  • Magnetic hyperthermia

ASJC Scopus subject areas

  • Electrochemistry
  • Chemical Engineering(all)

Cite this

Synthesis of cobalt ferrite nanoparticles using spermine and their effect on death in human breast cancer cells under an alternating magnetic field. / Matsuda, Shofu; Nakanishi, Takuya; Kaneko, Kisako; Osaka, Tetsuya.

In: Electrochimica Acta, Vol. 183, 20.11.2015, p. 153-159.

Research output: Contribution to journalArticle

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AB - To compare heat generation under an AC magnetic field for inducing cancer cell death, CoFe2O4 and Fe3O4 nanoparticles with a diameter of ∼10 nm were synthesized by hydrolysis in an aqueous solution containing the metal chlorides iron(III) chloride and cobalt(II) or iron(II) chloride, with spermine or N,N'-bis(3-aminopropyl)butane-1,4-diamine, as a base and a protective reagent. Both CoFe2O4 and Fe3O4 nanoparticles were incorporated into human breast cancer MCF-7 cells; the nanoparticles exhibited little toxicity on the cells. When the cells containing nanoparticles were subjected to an AC magnetic field, MCF-7 cell death was induced by heat generated from ∼10-nm CoFe2O4 nanoparticles but not from ∼10-nm Fe3O4 nanoparticles. An increase in coercivity derived from the substitution of Fe2+ with Co2+ facilitated the ability of the nanoparticles to induce cell death in human breast cancer cells under an AC magnetic field.

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