Synthesis of cycloalkanone-fused cyclopropanes by Au(I)-catalyzed oxidative ene-yne cyclizations

Yuta Uetake, Takashi Niwa, Masahisa Nakada

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Au(I)-catalyzed oxidative cyclizations that successfully convert 1,5-ene-ynes and a 1,6-ene-yne to the corresponding cycloalkanone-fused cyclopropanes are described. This Au(I)-catalyzed oxidative cyclization can be effectively applied to various substrates and is an alternative to the previously used intramolecular cyclopropanation that required potentially explosive diazo compound.

Original languageEnglish
Pages (from-to)6847-6850
Number of pages4
JournalTetrahedron Letters
Volume55
Issue number50
DOIs
Publication statusPublished - 2014 Dec 10

Keywords

  • Au(I)-catalysis
  • Cycloalkanone
  • Cyclopropane
  • Ene-yne cyclization
  • Oxidative cyclization

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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