Synthesis of cycloalkanone-fused cyclopropanes by Au(I)-catalyzed oxidative ene-yne cyclizations

Yuta Uetake, Takashi Niwa, Masahisa Nakada

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Au(I)-catalyzed oxidative cyclizations that successfully convert 1,5-ene-ynes and a 1,6-ene-yne to the corresponding cycloalkanone-fused cyclopropanes are described. This Au(I)-catalyzed oxidative cyclization can be effectively applied to various substrates and is an alternative to the previously used intramolecular cyclopropanation that required potentially explosive diazo compound.

    Original languageEnglish
    Pages (from-to)6847-6850
    Number of pages4
    JournalTetrahedron Letters
    Volume55
    Issue number50
    DOIs
    Publication statusPublished - 2014 Dec 10

    Fingerprint

    Cyclopropanes
    Cyclization
    Substrates

    Keywords

    • Au(I)-catalysis
    • Cycloalkanone
    • Cyclopropane
    • Ene-yne cyclization
    • Oxidative cyclization

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    Synthesis of cycloalkanone-fused cyclopropanes by Au(I)-catalyzed oxidative ene-yne cyclizations. / Uetake, Yuta; Niwa, Takashi; Nakada, Masahisa.

    In: Tetrahedron Letters, Vol. 55, No. 50, 10.12.2014, p. 6847-6850.

    Research output: Contribution to journalArticle

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