Synthesis of fluoride-releasing carbonate apatites for bone substitutes

Yu Sogo, Atsuo Ito, Daiki Yokoyama, Atsushi Yamazaki, Racquel Z. LeGeros

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Fluoride (F-)-substituted B-type carbonate hydroxyapatite (CHAP) powders were prepared for application as bone substitute materials having the ability to enhance bone formation and to suppress bone resorption due to the therapeutic effect of F-. F- was adsorbed on CHAP in a sodium fluoride solution followed by heating at 700°C in carbon dioxide flow to substitute F- for the hydroxyl ion in the CHAP structure. The F- contents in the F-substituted CHAP powders were 16-22 times greater than that in normal adult human bones. The carbonate ion contents in the F-substituted CHAP powders corresponded to or were higher than that in normal adult human bones. F-substituted CHAP powder with CO 3 2- and F- contents of 11.03 and 0.66 wt%, respectively, slowly released F- in a physiological salt solution to a sufficiently high F - level. The F- concentration slowly increased and reached 67.20 ± 4.81 μg l-1, which was 1.5-9.3 times higher than that in the body fluid of normal adult humans, near the therapeutic window of F-, and far lower than the estimated toxic level. Therefore, the F-substituted CHAP can promote bone formation. The present F-substituted CHAP has the advantage of slow F- release over sodium fluoride and sodium monofluorophosphate which are highly soluble salts and cannot be sintered into a ceramic body.

    Original languageEnglish
    Pages (from-to)1001-1007
    Number of pages7
    JournalJournal of Materials Science: Materials in Medicine
    Volume18
    Issue number6
    DOIs
    Publication statusPublished - 2007 Jun

    Fingerprint

    Bone Substitutes
    Carbonates
    Apatite
    Fluorides
    Durapatite
    Hydroxyapatite
    Bone
    Powders
    Sodium Fluoride
    Sodium
    fluorophosphate
    Osteogenesis
    Salts
    carboapatite
    Bone and Bones
    Poisons
    Body fluids
    Ions
    Ceramics
    Body Fluids

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering
    • Chemical Engineering(all)

    Cite this

    Synthesis of fluoride-releasing carbonate apatites for bone substitutes. / Sogo, Yu; Ito, Atsuo; Yokoyama, Daiki; Yamazaki, Atsushi; LeGeros, Racquel Z.

    In: Journal of Materials Science: Materials in Medicine, Vol. 18, No. 6, 06.2007, p. 1001-1007.

    Research output: Contribution to journalArticle

    Sogo, Yu ; Ito, Atsuo ; Yokoyama, Daiki ; Yamazaki, Atsushi ; LeGeros, Racquel Z. / Synthesis of fluoride-releasing carbonate apatites for bone substitutes. In: Journal of Materials Science: Materials in Medicine. 2007 ; Vol. 18, No. 6. pp. 1001-1007.
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