Synthesis of Hexameric Manganese Porphyrin as an SOD Mimic and SOD Activity

Makoto Yuasa, Kenichi Oyaizu, Yukihiro Hanyuu, Takamitsu Hayashi, Aritomo Yamaguchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Free radicals and related species derived from O2 such as superoxide anion radical (O2-·), hydrogen peroxide (H2O2), hydroxyl radical (·OH) and peroxynitrite ion (ONOO-) are often generated in organisms with possibly consequent diseases. The enzyme, superoxide dismutase (SOD), catalyzes the reaction which eliminates O2-· As models of SOD, manganese porphyrins such as [meso-tetrakis(N-methylpyridinium-4-yl)porphyrinato] manganese(III) (MnT4MPyP) have been investigated. However, the half-life of any one of these in the blood is usually quite short. We undertook the design of a novel hexameric manganese porphyrin (HexMnP) capable of remaining for a prolonged period in the blood. The SOD activity of HexMnP (IC50 = 2.1±0.7 μM) was found to be somewhat less than that of MnT4MPyP (IC50 = 0.71 μM), but to exceed that of reconstituted hemoglobin (MnT4MPyP-Hb) (IC50 = 2.0 μM) prepared in a previous study. HexMnP proved to be an effective SOD model in which HexMnP had the capacity to remain over a long period of time in the blood, owing to its molecular diameter of more than 80Å.

Original languageEnglish
Pages (from-to)513-518
Number of pages6
JournalJournal of oleo science
Volume54
Issue number9
DOIs
Publication statusPublished - 2005 Jan 1
Externally publishedYes

Keywords

  • cationic manganese porphyrin
  • hexameric manganese porphyrin
  • superoxide dismutase mimic

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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