Synthesis of magnetic nanoparticles and their application to bioassays

Tetsuya Osaka; Tadashi Matsunaga; Takuya Nakanishi; Atsushi Arakaki; Daisuke Niwa; Hironori Iida

doi:10.1007/s00216-005-0255-7

Synthesis of magnetic nanoparticles and their application to bioassays

Tetsuya Osaka, Tadashi Matsunaga, Takuya Nakanishi, Atsushi Arakaki, Daisuke Niwa, Hironori Iida

Research output: Contribution to journal › Article

150 Citations (Scopus)

Abstract

Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.

Original language	English
Pages (from-to)	593-600
Number of pages	8
Journal	Analytical and Bioanalytical Chemistry
Volume	384
Issue number	3
DOIs	https://doi.org/10.1007/s00216-005-0255-7
Publication status	Published - 2006 Feb

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Keywords

Biomolecule detection
Iron oxide
Magnetic nanoparticle
Patterned surface
Surface modification

ASJC Scopus subject areas

Analytical Chemistry
Clinical Biochemistry

Cite this

Osaka, T., Matsunaga, T., Nakanishi, T., Arakaki, A., Niwa, D., & Iida, H. (2006). Synthesis of magnetic nanoparticles and their application to bioassays. Analytical and Bioanalytical Chemistry, 384(3), 593-600. https://doi.org/10.1007/s00216-005-0255-7

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10.1007/s00216-005-0255-7