Synthesis of magnetic nanoparticles and their application to bioassays

Tetsuya Osaka; Tadashi Matsunaga; Takuya Nakanishi; Atsushi Arakaki; Daisuke Niwa; Hironori Iida

doi:10.1007/s00216-005-0255-7

Synthesis of magnetic nanoparticles and their application to bioassays

Tetsuya Osaka, Tadashi Matsunaga, Takuya Nakanishi, Atsushi Arakaki, Daisuke Niwa, Hironori Iida

Research Organization for Nano & Life Innovation

Research output: Contribution to journal › Review article › peer-review

155 Citations (Scopus)

Abstract

Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.

Original language	English
Pages (from-to)	593-600
Number of pages	8
Journal	Analytical and Bioanalytical Chemistry
Volume	384
Issue number	3
DOIs	https://doi.org/10.1007/s00216-005-0255-7
Publication status	Published - 2006 Feb 1

Keywords

Biomolecule detection
Iron oxide
Magnetic nanoparticle
Patterned surface
Surface modification

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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Cite this

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AU - Osaka, Tetsuya

AU - Matsunaga, Tadashi

AU - Nakanishi, Takuya

AU - Arakaki, Atsushi

AU - Niwa, Daisuke

AU - Iida, Hironori

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AB - Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.

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KW - Magnetic nanoparticle

KW - Patterned surface

KW - Surface modification

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