TY - JOUR
T1 - Synthesis of magnetic nanoparticles and their application to bioassays
AU - Osaka, Tetsuya
AU - Matsunaga, Tadashi
AU - Nakanishi, Takuya
AU - Arakaki, Atsushi
AU - Niwa, Daisuke
AU - Iida, Hironori
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
AB - Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
KW - Biomolecule detection
KW - Iron oxide
KW - Magnetic nanoparticle
KW - Patterned surface
KW - Surface modification
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U2 - 10.1007/s00216-005-0255-7
DO - 10.1007/s00216-005-0255-7
M3 - Review article
C2 - 16402174
AN - SCOPUS:32544439539
VL - 384
SP - 593
EP - 600
JO - Fresenius Zeitschrift fur Analytische Chemie
JF - Fresenius Zeitschrift fur Analytische Chemie
SN - 0016-1152
IS - 3
ER -