Abstract
Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
| Original language | English |
|---|---|
| Pages (from-to) | 593-600 |
| Number of pages | 8 |
| Journal | Analytical and Bioanalytical Chemistry |
| Volume | 384 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2006 Feb |
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Keywords
- Biomolecule detection
- Iron oxide
- Magnetic nanoparticle
- Patterned surface
- Surface modification
ASJC Scopus subject areas
- Analytical Chemistry
- Clinical Biochemistry
Cite this
Synthesis of magnetic nanoparticles and their application to bioassays. / Osaka, Tetsuya; Matsunaga, Tadashi; Nakanishi, Takuya; Arakaki, Atsushi; Niwa, Daisuke; Iida, Hironori.
In: Analytical and Bioanalytical Chemistry, Vol. 384, No. 3, 02.2006, p. 593-600.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of magnetic nanoparticles and their application to bioassays
AU - Osaka, Tetsuya
AU - Matsunaga, Tadashi
AU - Nakanishi, Takuya
AU - Arakaki, Atsushi
AU - Niwa, Daisuke
AU - Iida, Hironori
PY - 2006/2
Y1 - 2006/2
N2 - Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
AB - Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.
KW - Biomolecule detection
KW - Iron oxide
KW - Magnetic nanoparticle
KW - Patterned surface
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=32544439539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32544439539&partnerID=8YFLogxK
U2 - 10.1007/s00216-005-0255-7
DO - 10.1007/s00216-005-0255-7
M3 - Article
C2 - 16402174
AN - SCOPUS:32544439539
VL - 384
SP - 593
EP - 600
JO - Fresenius Zeitschrift fur Analytische Chemie
JF - Fresenius Zeitschrift fur Analytische Chemie
SN - 0016-1152
IS - 3
ER -