Synthesis of medium-sized carbocyclic ketones via the intramolecular B-alkyl Liebeskind-Srogl coupling reaction

Kazuhiro Tsuna, Naoyoshi Noguchi, Masahisa Nakada

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    4 Citations (Scopus)

    Abstract

    Synthesis of medium-sized carbocyclic ketones via the intramolecular B-alkyl Liebeskind-Srogl coupling reaction is described. The sequence of hydroboration of ω-alkenyl thiol ester with 9-BBN and the Liebeskind-Srogl reaction results in the formation of medium-sized carbocyclic ketones with good yield.

    Original languageEnglish
    Pages (from-to)7202-7205
    Number of pages4
    JournalTetrahedron Letters
    Volume52
    Issue number52
    DOIs
    Publication statusPublished - 2011 Dec 28

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    Keywords

    • Intramolecular coupling reaction
    • Liebeskind-Srogl coupling reaction
    • Medium-sized carbocyclic ketone
    • Palladium-mediated reaction

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

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