Synthesis of medium-sized carbocyclic ketones via the intramolecular B-alkyl Liebeskind-Srogl coupling reaction is described. The sequence of hydroboration of ω-alkenyl thiol ester with 9-BBN and the Liebeskind-Srogl reaction results in the formation of medium-sized carbocyclic ketones with good yield.
- Intramolecular coupling reaction
- Liebeskind-Srogl coupling reaction
- Medium-sized carbocyclic ketone
- Palladium-mediated reaction
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry