Synthesis of medium-sized carbocyclic ketones via the intramolecular B-alkyl Liebeskind-Srogl coupling reaction

Kazuhiro Tsuna, Naoyoshi Noguchi, Masahisa Nakada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Synthesis of medium-sized carbocyclic ketones via the intramolecular B-alkyl Liebeskind-Srogl coupling reaction is described. The sequence of hydroboration of ω-alkenyl thiol ester with 9-BBN and the Liebeskind-Srogl reaction results in the formation of medium-sized carbocyclic ketones with good yield.

Original languageEnglish
Pages (from-to)7202-7205
Number of pages4
JournalTetrahedron Letters
Volume52
Issue number52
DOIs
Publication statusPublished - 2011 Dec 28

Keywords

  • Intramolecular coupling reaction
  • Liebeskind-Srogl coupling reaction
  • Medium-sized carbocyclic ketone
  • Palladium-mediated reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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