Abstract
We have achieved a synthesis of multiply arylated pyridines by using a [4 + 2] cycloaddition of 2,4-diaryl-5-chloroxazoles and cinnamic acids as a key reaction. The resulting hydroxytriarylpyridines can be derivatized into triarylpyridines, tetraarylpyridines and pentaarylpyridines by sequential cross-couplings. This synthetic method allows for facile and rapid access to highly arylated pyridines with different aryl substituents.
Original language | English |
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Pages (from-to) | 3669-3676 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 73 |
Issue number | 26 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Cross-coupling
- Heterocyclic compound
- Palladium
- Pyridine
- Ring transformation
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry