Synthesis of mycophenolic acid by palladium-catalyzed three component coupling reaction

I. Shimizu, Y. Lee, Y. Fujiwara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Reaction of aromatic iodide 3 with isoprene and dimethyl malonate in the presence of palladium(0) catalyst gave the coupling product 4, which was converted into mycophenolic acid (1) in three steps.

Original languageEnglish
Pages (from-to)1285-1286
Number of pages2
JournalSynlett
Issue number9
Publication statusPublished - 2000

Keywords

  • π-allylpalladium intermediate
  • Mycophenolic acid
  • Palladium(0)
  • Phthalide
  • Three component coupling reaction

ASJC Scopus subject areas

  • Organic Chemistry

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  • Cite this

    Shimizu, I., Lee, Y., & Fujiwara, Y. (2000). Synthesis of mycophenolic acid by palladium-catalyzed three component coupling reaction. Synlett, (9), 1285-1286.