Synthesis of mycophenolic acid by palladium-catalyzed three component coupling reaction

I. Shimizu, Y. Lee, Y. Fujiwara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Reaction of aromatic iodide 3 with isoprene and dimethyl malonate in the presence of palladium(0) catalyst gave the coupling product 4, which was converted into mycophenolic acid (1) in three steps.

Original languageEnglish
Pages (from-to)1285-1286
Number of pages2
JournalSynlett
Issue number9
Publication statusPublished - 2000

Fingerprint

Mycophenolic Acid
Palladium
Iodides
Catalysts
isoprene
methyl malonate

Keywords

  • π-allylpalladium intermediate
  • Mycophenolic acid
  • Palladium(0)
  • Phthalide
  • Three component coupling reaction

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Shimizu, I., Lee, Y., & Fujiwara, Y. (2000). Synthesis of mycophenolic acid by palladium-catalyzed three component coupling reaction. Synlett, (9), 1285-1286.

Synthesis of mycophenolic acid by palladium-catalyzed three component coupling reaction. / Shimizu, I.; Lee, Y.; Fujiwara, Y.

In: Synlett, No. 9, 2000, p. 1285-1286.

Research output: Contribution to journalArticle

Shimizu, I, Lee, Y & Fujiwara, Y 2000, 'Synthesis of mycophenolic acid by palladium-catalyzed three component coupling reaction', Synlett, no. 9, pp. 1285-1286.
Shimizu, I. ; Lee, Y. ; Fujiwara, Y. / Synthesis of mycophenolic acid by palladium-catalyzed three component coupling reaction. In: Synlett. 2000 ; No. 9. pp. 1285-1286.
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