The synthesis of natural products and pharmaceuticals, particularly those containing heterocyclic frameworks, can be dramatically simplified by using catalytic C-H functionalization. C-H functionalization has gathered significant interest from the organic synthesis community because it provides a new strategy to construct carbon-carbon and carbon-heteroatom bonds in highly functionalized, complex molecules without prefunctionalization. In this book chapter, methods in heterocycle substitution and synthesis using catalytic C-H functionalization are classified by heterocycle, with specific focus on the cutting-edge synthesis of natural products and pharmaceuticals.
|Title of host publication||Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation|
|Number of pages||46|
|Publication status||Published - 2016 Jan 12|
- C-H functionalization
- Natural products
ASJC Scopus subject areas
- Materials Science(all)