Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers

Eishun Tsuchida, Hiroyuki Nishide, Etsuo Hasegawa, Yuzuru Chika, Masaki Fukuzumi, Teruyuki Komatsu

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Abstract

Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.

Original languageEnglish
Pages (from-to)255-264
Number of pages10
JournalJournal of Inorganic Biochemistry
Volume49
Issue number4
DOIs
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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