Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers

Eishun Tsuchida, Hiroyuki Nishide, Etsuo Hasegawa, Yuzuru Chika, Masaki Fukuzumi, Teruyuki Komatsu

Research output: Contribution to journalArticle

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Abstract

Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.

Original languageEnglish
Pages (from-to)255-264
Number of pages10
JournalJournal of Inorganic Biochemistry
Volume49
Issue number4
DOIs
Publication statusPublished - 1993

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Lipid bilayers
Lipid Bilayers
Heme
Phospholipids
Lipids
Phosphoserine
Hemoglobins
Blood
Erythrocytes
Cells
Oxygen

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers. / Tsuchida, Eishun; Nishide, Hiroyuki; Hasegawa, Etsuo; Chika, Yuzuru; Fukuzumi, Masaki; Komatsu, Teruyuki.

In: Journal of Inorganic Biochemistry, Vol. 49, No. 4, 1993, p. 255-264.

Research output: Contribution to journalArticle

Tsuchida, Eishun ; Nishide, Hiroyuki ; Hasegawa, Etsuo ; Chika, Yuzuru ; Fukuzumi, Masaki ; Komatsu, Teruyuki. / Synthesis of porphinatoirons having an alkyl amphiphilic chain and their O2 binding properties in lipid bilayers. In: Journal of Inorganic Biochemistry. 1993 ; Vol. 49, No. 4. pp. 255-264.
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AU - Fukuzumi, Masaki

AU - Komatsu, Teruyuki

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