Synthesis of six-coordination proximal base conjugation iron (III) porphyrin complexes and evaluation as a superoxide sensor

Makoto Yuasa, Kenichi Oyaizu, Hidenori Murata, Yujiro Toyoda, Masahiro Namba, Masaki Shitara

Research output: Contribution to journalArticle

Abstract

Reactive oxygen species (ROS) such as the superoxide anion radical (O2 -•) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2 -• homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as a cancer, brain and mitocondrial infarction, and inflammation. Therefore, quantitative measurement of O2 1• in vivo is important for clarifying their relationship under various conditions. However, in most cases, the biological significance and mechanism of the O2 1• generation are not well understood yet. We have developed a O2 1• sensor composed of a thin film of N-methylimidazole-coordinated iron meso-tetra (3-thienyl) porphyrin ((Im)2FeT3ThP) for the electrochemical detection of O2 -•. The microsensor displayed high selectivity and activity for the oxidation of O2 -• and showed a linear relationship between electric current and O2 -• concentration. In this study, we have designed and synthesized a novel hexa-coordinated iron (III) porphyrin compound, which is more stable than the meso-tetra (3-thienyl) porphyrin coordinating imidazoles. This compound was electropolymerized onto the electrode and used as a O2 -• sensor. The redox potential of the electrode suggests that the molecular structure in the electropolymerized film is maintained. This novel modified electrode displayed a high activity for the oxidation of O2 -• even in the presence of H2O2 and showed a linear relationship between the electric current and O2 -• concentration.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalKobunshi Ronbunshu
Volume65
Issue number5
DOIs
Publication statusPublished - 2008 May
Externally publishedYes

Fingerprint

porphyrin
Porphyrins
Superoxides
electrode
Iron
homeostasis
Electric currents
sensor
iron
Electrodes
Reactive Oxygen Species
Sensors
Imidazoles
oxidation
Oxidation
Microsensors
Oxygen
Oxidative stress
redox potential
Molecular structure

Keywords

  • Electrocatalyst
  • Electropolymerization
  • Sensor
  • Six-coordinate-iron(III)porphyrin
  • Superoxide anion radical

ASJC Scopus subject areas

  • Polymers and Plastics
  • Environmental Science(all)
  • Materials Science (miscellaneous)
  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites

Cite this

Synthesis of six-coordination proximal base conjugation iron (III) porphyrin complexes and evaluation as a superoxide sensor. / Yuasa, Makoto; Oyaizu, Kenichi; Murata, Hidenori; Toyoda, Yujiro; Namba, Masahiro; Shitara, Masaki.

In: Kobunshi Ronbunshu, Vol. 65, No. 5, 05.2008, p. 349-354.

Research output: Contribution to journalArticle

Yuasa, Makoto ; Oyaizu, Kenichi ; Murata, Hidenori ; Toyoda, Yujiro ; Namba, Masahiro ; Shitara, Masaki. / Synthesis of six-coordination proximal base conjugation iron (III) porphyrin complexes and evaluation as a superoxide sensor. In: Kobunshi Ronbunshu. 2008 ; Vol. 65, No. 5. pp. 349-354.
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AU - Namba, Masahiro

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