Synthesis of six-coordination proximal base conjugation iron (III) porphyrin complexes and evaluation as a superoxide sensor

Makoto Yuasa, Kenichi Oyaizu, Hidenori Murata, Yujiro Toyoda, Masahiro Namba, Masaki Shitara

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Reactive oxygen species (ROS) such as the superoxide anion radical (O2-•) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2-• homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as a cancer, brain and mitocondrial infarction, and inflammation. Therefore, quantitative measurement of O2 1• in vivo is important for clarifying their relationship under various conditions. However, in most cases, the biological significance and mechanism of the O2 1• generation are not well understood yet. We have developed a O21• sensor composed of a thin film of N-methylimidazole-coordinated iron meso-tetra (3-thienyl) porphyrin ((Im)2FeT3ThP) for the electrochemical detection of O2-•. The microsensor displayed high selectivity and activity for the oxidation of O2 -• and showed a linear relationship between electric current and O2-• concentration. In this study, we have designed and synthesized a novel hexa-coordinated iron (III) porphyrin compound, which is more stable than the meso-tetra (3-thienyl) porphyrin coordinating imidazoles. This compound was electropolymerized onto the electrode and used as a O2 -• sensor. The redox potential of the electrode suggests that the molecular structure in the electropolymerized film is maintained. This novel modified electrode displayed a high activity for the oxidation of O2-• even in the presence of H2O2 and showed a linear relationship between the electric current and O2-• concentration.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalKOBUNSHI RONBUNSHU
Volume65
Issue number5
DOIs
Publication statusPublished - 2008 May
Externally publishedYes

Keywords

  • Electrocatalyst
  • Electropolymerization
  • Sensor
  • Six-coordinate-iron(III)porphyrin
  • Superoxide anion radical

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

Fingerprint Dive into the research topics of 'Synthesis of six-coordination proximal base conjugation iron (III) porphyrin complexes and evaluation as a superoxide sensor'. Together they form a unique fingerprint.

Cite this