Synthesis of 2 diastereoisomers of A/B fragments of ciguatoxin was achieved by connecting a hexose and 2 pentose derivatives with silylacetylene. The key steps are the cationic cyclization and reductive decomplexation of the acetylene biscobalthexacarbonyl complex.
- Two diastereoisomers were synthesized from D-glucose and D-arabinose or L-xylose derivatives as partial model compounds for the A/B ring of ciguatoxin.
ASJC Scopus subject areas
- Organic Chemistry