Synthesizing a Trefoil Knotted Block Copolymer via Ring-Expansion Strategy

Peng Fei Cao, Li Han Rong, Joey Dacula Mangadlao, Rigoberto C. Advincula*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


A synthetic trefoil knotted poly(ε-caprolatone)-block-poly(l-lactide) (TK-PLA-b-PCL) is synthesized via a ring-expansion strategy from a trefoil knotted tin (Sn) initiator. Ring-closing reaction between the bis-copper(I) templated phenanthroline complex and dibutyldimethoxytin results in a templated trefoil knotted initiator. The bis-copper(I) templated trefoil knotted poly(l-lactide) (TK-PLA) can be synthesized by ring-opening polymerization of l-lactide monomer, and decomplexation reaction of the templated TK-PLA will result in a geniune TK-PLA without constraint from the copper template. Subsequent insertion of ε-caprolactone in the bis-copper(I) templated TK-PLA forms the templated trefoil knotted block copolymer, i.e., TK-PLA-b-PCL, and the copper-free TK-PLA-b-PCL can be obtained by decomplexation reaction. Both TK-PLA and TK-PLA-b-PCL are analyzed by the 1H NMR, FT-IR, UV-vis, DLS, and GPC.

Original languageEnglish
Pages (from-to)1473-1481
Number of pages9
Issue number4
Publication statusPublished - 2017 Feb 28
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry


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