Synthetic microfluidic paper allows controlled receptor positioning and improved readout signal intensity in lateral flow assays

Jonas Hansson, Aurore Quelennec, Hiroki Yasuga, Tommy Haraldsson, Wouter Van Der Wijngaart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Synthetic Microfluidic Paper consists of slanted and interlocked polymer micropillars and can be used as a porous substrate in microfluidics and lateral flow assays. We here demonstrate single step manufacturing of multiple Synthetic Microfluidic Paper densities in the same device, and passive alignment of liquid spots in denser substrate regions, regardless of spotting position, allowing increased control of receptor positioning for lateral flow assays. We further demonstrate that the transparency of Synthetic Microfluidic Paper allows increasing readout signal intensity with increasing substrate thickness, to a value 3 times larger compared to nitrocellulose substrates.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages284-286
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015 Jan 1
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

Keywords

  • Lab on Chip
  • Lateral flow assay
  • Microfluidics
  • Micropillar array
  • OSTE
  • Paper microfluidics
  • Receptor spotting

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Hansson, J., Quelennec, A., Yasuga, H., Haraldsson, T., & Van Der Wijngaart, W. (2015). Synthetic microfluidic paper allows controlled receptor positioning and improved readout signal intensity in lateral flow assays. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 284-286). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.