Synthetic microfluidic paper: High surface area and high porosity polymer micropillar arrays

Jonas Hansson, Hiroki Yasuga, Tommy Haraldsson, Wouter Van Der Wijngaart

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We introduce Synthetic Microfluidic Paper, a novel porous material for microfluidic applications that consists of an OSTE polymer that is photostructured in a well-controlled geometry of slanted and interlocked micropillars. We demonstrate the distinct benefits of Synthetic Microfluidic Paper over other porous microfluidic materials, such as nitrocellulose, traditional paper and straight micropillar arrays: in contrast to straight micropillar arrays, the geometry of Synthetic Microfluidic Paper was miniaturized without suffering capillary collapse during manufacturing and fluidic operation, resulting in a six-fold increased internal surface area and a three-fold increased porous fraction. Compared to commercial nitrocellulose materials for capillary assays, Synthetic Microfluidic Paper shows a wider range of capillary pumping speed and four times lower device-to-device variation. Compared to the surfaces of the other porous microfluidic materials that are modified by adsorption, Synthetic Microfluidic Paper contains free thiol groups and has been shown to be suitable for covalent surface chemistry, demonstrated here for increasing the material hydrophilicity. These results illustrate the potential of Synthetic Microfluidic Paper as a porous microfluidic material with improved performance characteristics, especially for bioassay applications such as diagnostic tests.

Original languageEnglish
Pages (from-to)298-304
Number of pages7
JournalLab on a Chip
Volume16
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Fingerprint

Microfluidics
Porosity
Polymers
Nitrocellulose
Collodion
Equipment and Supplies
Geometry
Bioassay
Hydrophilicity
Fluidics
Surface chemistry
Hydrophobic and Hydrophilic Interactions
Routine Diagnostic Tests
Sulfhydryl Compounds
Biological Assay
Adsorption
Porous materials
Assays

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Hansson, J., Yasuga, H., Haraldsson, T., & Van Der Wijngaart, W. (2016). Synthetic microfluidic paper: High surface area and high porosity polymer micropillar arrays. Lab on a Chip, 16(2), 298-304. https://doi.org/10.1039/c5lc01318f

Synthetic microfluidic paper : High surface area and high porosity polymer micropillar arrays. / Hansson, Jonas; Yasuga, Hiroki; Haraldsson, Tommy; Van Der Wijngaart, Wouter.

In: Lab on a Chip, Vol. 16, No. 2, 01.01.2016, p. 298-304.

Research output: Contribution to journalArticle

Hansson, J, Yasuga, H, Haraldsson, T & Van Der Wijngaart, W 2016, 'Synthetic microfluidic paper: High surface area and high porosity polymer micropillar arrays', Lab on a Chip, vol. 16, no. 2, pp. 298-304. https://doi.org/10.1039/c5lc01318f
Hansson, Jonas ; Yasuga, Hiroki ; Haraldsson, Tommy ; Van Der Wijngaart, Wouter. / Synthetic microfluidic paper : High surface area and high porosity polymer micropillar arrays. In: Lab on a Chip. 2016 ; Vol. 16, No. 2. pp. 298-304.
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