Synthetic studies on cyathins: Enantioselective total synthesis of (+)-allocyathin B2

Masashi Takano, Akinori Umino, Masahisa Nakada

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Abstract

(Chemical Equation Presented) The enantioselective total synthesis of (+)-allocyathin B2 has been achieved. Our approach features a convergent enantioselective construction of the 5-6-7 tricyclic core system using the originally developed chiral building blocks via asymmetric catalysis, the intramolecular aldol reaction in high yield, successful samarium diiodide-mediated ring expansion, and a newly developed double-bond installation method.

Original languageEnglish
Pages (from-to)4897-4900
Number of pages4
JournalOrganic Letters
Volume6
Issue number26
DOIs
Publication statusPublished - 2004 Dec 23

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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