Synthetic studies on taxol

Highly stereoselective construction of the taxol C-ring via SN2′ reduction of an allylic phosphonium salt

Masayuki Utsugi, Masayuki Miyano, Masahisa Nakada

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    The highly stereoselective construction of the C3 stereogenic center of the taxol C-ring is described. The trans isomer at the C3-C8 position of the taxol C-ring, which is required for the total synthesis, as well as its diastereomeric cis isomer were successfully synthesized with highly diastereoselective S N2′ reduction of the allylic phosphonium salts.

    Original languageEnglish
    Pages (from-to)2973-2976
    Number of pages4
    JournalOrganic Letters
    Volume8
    Issue number14
    DOIs
    Publication statusPublished - 2006 Jul 6

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    Paclitaxel
    Isomers
    isomers
    Salts
    salts
    rings
    synthesis

    ASJC Scopus subject areas

    • Molecular Medicine

    Cite this

    Synthetic studies on taxol : Highly stereoselective construction of the taxol C-ring via SN2′ reduction of an allylic phosphonium salt. / Utsugi, Masayuki; Miyano, Masayuki; Nakada, Masahisa.

    In: Organic Letters, Vol. 8, No. 14, 06.07.2006, p. 2973-2976.

    Research output: Contribution to journalArticle

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