Synthetic studies on taxol: Highly stereoselective construction of the taxol C-ring via SN2′ reduction of an allylic phosphonium salt

Masayuki Utsugi, Masayuki Miyano, Masahisa Nakada

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The highly stereoselective construction of the C3 stereogenic center of the taxol C-ring is described. The trans isomer at the C3-C8 position of the taxol C-ring, which is required for the total synthesis, as well as its diastereomeric cis isomer were successfully synthesized with highly diastereoselective S N2′ reduction of the allylic phosphonium salts.

Original languageEnglish
Pages (from-to)2973-2976
Number of pages4
JournalOrganic Letters
Volume8
Issue number14
DOIs
Publication statusPublished - 2006 Jul 6

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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