Synthetic studies on the taxane skeleton: Construction of eight-membered carbocyclic rings by the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction

Hatsuo Kawada, Mitsuhiro Iwamoto, Masayuki Utsugi, Masayuki Miyano, Masahisa Nakada

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    Abstract

    (Chemical equation presented) Construction of eight-membered carbocyclic rings via the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction has been studied. This protocol proved its potency through the formation of the eight-membered ring possessing a quaternary carbon on its ring in high yield, affording promise of a new access to the eight-membered ring of Taxol.

    Original languageEnglish
    Pages (from-to)4491-4494
    Number of pages4
    JournalOrganic Letters
    Volume6
    Issue number24
    DOIs
    Publication statusPublished - 2004 Nov 25

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    ASJC Scopus subject areas

    • Molecular Medicine

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