Synthetic studies on the taxane skeleton: Construction of eight-membered carbocyclic rings by the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction

Hatsuo Kawada, Mitsuhiro Iwamoto, Masayuki Utsugi, Masayuki Miyano, Masahisa Nakada

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

(Chemical equation presented) Construction of eight-membered carbocyclic rings via the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction has been studied. This protocol proved its potency through the formation of the eight-membered ring possessing a quaternary carbon on its ring in high yield, affording promise of a new access to the eight-membered ring of Taxol.

Original languageEnglish
Pages (from-to)4491-4494
Number of pages4
JournalOrganic Letters
Volume6
Issue number24
DOIs
Publication statusPublished - 2004 Nov 25

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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