TY - JOUR
T1 - Synthetic study on an antitumor antibiotic rhizoxin by using an enzymatic process on prochiral B-substituted glutarates
AU - Kobayashi, Susumu
AU - Nakada, Masahisa
AU - Ohno, Masaji
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Enantio- and stereoselective synthesis of the right-half segment (1, C1-C9) of macrolide antibiotic rhizoxin was achieved by enzymatic approach. Characteristic features of the present synthesis are (1) enantioselective hydrolysis of prochiral p-substituted glutarates with pig liver esterase, and (2) stereoselective cyclichydroboration of the 1,5-diene 8.
AB - Enantio- and stereoselective synthesis of the right-half segment (1, C1-C9) of macrolide antibiotic rhizoxin was achieved by enzymatic approach. Characteristic features of the present synthesis are (1) enantioselective hydrolysis of prochiral p-substituted glutarates with pig liver esterase, and (2) stereoselective cyclichydroboration of the 1,5-diene 8.
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U2 - 10.1351/pac199264081121
DO - 10.1351/pac199264081121
M3 - Article
AN - SCOPUS:0039574411
SN - 0033-4545
VL - 64
SP - 1121
EP - 1124
JO - Pure and Applied Chemistry
JF - Pure and Applied Chemistry
IS - 8
ER -