Synthetic study on an antitumor antibiotic rhizoxin by using an enzymatic process on prochiral B-substituted glutarates

Susumu Kobayashi, Masahisa Nakada, Masaji Ohno

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Enantio- and stereoselective synthesis of the right-half segment (1, C1-C9) of macrolide antibiotic rhizoxin was achieved by enzymatic approach. Characteristic features of the present synthesis are (1) enantioselective hydrolysis of prochiral p-substituted glutarates with pig liver esterase, and (2) stereoselective cyclichydroboration of the 1,5-diene 8.

Original languageEnglish
Pages (from-to)1121-1124
Number of pages4
JournalPure and Applied Chemistry
Volume64
Issue number8
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

Fingerprint

Glutarates
Antibiotics
Anti-Bacterial Agents
Macrolides
Esterases
Liver
Hydrolysis
rhizoxin

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Synthetic study on an antitumor antibiotic rhizoxin by using an enzymatic process on prochiral B-substituted glutarates. / Kobayashi, Susumu; Nakada, Masahisa; Ohno, Masaji.

In: Pure and Applied Chemistry, Vol. 64, No. 8, 01.01.1992, p. 1121-1124.

Research output: Contribution to journalArticle

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