Systemic administration of lentinan, a branched β-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo

Yoshikuni Edagawa; Miro Smriga; Nobuyoshi Nishiyama; Hiroshi Saito

doi:10.1016/S0304-3940(01)02301-1

Systemic administration of lentinan, a branched β-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo

Yoshikuni Edagawa, Miro Smriga, Nobuyoshi Nishiyama, Hiroshi Saito

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We investigated the effects of oral and intravenous application of lentinan, a branched β-glucan, on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vivo. Oral administration of lentinan (200 mg/kg) enhanced the induction of LTP evoked by sub-threshold tetanic stimulation (20 pulses at 60 Hz) of the perforant pathway without affecting normal synaptic potentials. Intravenous injection of the compound (0.2-10.0 mg/kg) also enhanced the induction of LTP in a bell-shaped manner, whereas it had no effect on LTP evoked by supra-threshold tetanic stimulation (100 pulses at 100 Hz). Structurally related β-glucans did not mimic the lentinan-triggered enhancement of LTP. These results suggest that peripherally applied lentinan facilitates the synaptic efficacy of the dentate gyrus neurons in vivo.

Original language	English
Pages (from-to)	139-142
Number of pages	4
Journal	Neuroscience Letters
Volume	314
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(01)02301-1
Publication status	Published - 2001 Nov 16
Externally published	Yes

Keywords

Dentate gyrus
Glucan
In vivo recording
Intravenous injection
Lentinan
Long-term potentiation
Oral application

ASJC Scopus subject areas

Neuroscience(all)

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title = "Systemic administration of lentinan, a branched β-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo",

abstract = "We investigated the effects of oral and intravenous application of lentinan, a branched β-glucan, on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vivo. Oral administration of lentinan (200 mg/kg) enhanced the induction of LTP evoked by sub-threshold tetanic stimulation (20 pulses at 60 Hz) of the perforant pathway without affecting normal synaptic potentials. Intravenous injection of the compound (0.2-10.0 mg/kg) also enhanced the induction of LTP in a bell-shaped manner, whereas it had no effect on LTP evoked by supra-threshold tetanic stimulation (100 pulses at 100 Hz). Structurally related β-glucans did not mimic the lentinan-triggered enhancement of LTP. These results suggest that peripherally applied lentinan facilitates the synaptic efficacy of the dentate gyrus neurons in vivo.",

keywords = "Dentate gyrus, Glucan, In vivo recording, Intravenous injection, Lentinan, Long-term potentiation, Oral application",

author = "Yoshikuni Edagawa and Miro Smriga and Nobuyoshi Nishiyama and Hiroshi Saito",

note = "Funding Information: We would like to thank Ajinomoto Co., Inc. for the gift of lentinan. This work was partially supported by a Grant-In-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to Y.E. (13771390).",

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doi = "10.1016/S0304-3940(01)02301-1",

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T1 - Systemic administration of lentinan, a branched β-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo

AU - Edagawa, Yoshikuni

AU - Smriga, Miro

AU - Nishiyama, Nobuyoshi

AU - Saito, Hiroshi

N1 - Funding Information: We would like to thank Ajinomoto Co., Inc. for the gift of lentinan. This work was partially supported by a Grant-In-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan to Y.E. (13771390).

PY - 2001/11/16

Y1 - 2001/11/16

N2 - We investigated the effects of oral and intravenous application of lentinan, a branched β-glucan, on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vivo. Oral administration of lentinan (200 mg/kg) enhanced the induction of LTP evoked by sub-threshold tetanic stimulation (20 pulses at 60 Hz) of the perforant pathway without affecting normal synaptic potentials. Intravenous injection of the compound (0.2-10.0 mg/kg) also enhanced the induction of LTP in a bell-shaped manner, whereas it had no effect on LTP evoked by supra-threshold tetanic stimulation (100 pulses at 100 Hz). Structurally related β-glucans did not mimic the lentinan-triggered enhancement of LTP. These results suggest that peripherally applied lentinan facilitates the synaptic efficacy of the dentate gyrus neurons in vivo.

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KW - Intravenous injection

KW - Lentinan

KW - Long-term potentiation

KW - Oral application

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