Abstract
We investigated the effects of oral and intravenous application of lentinan, a branched β-glucan, on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vivo. Oral administration of lentinan (200 mg/kg) enhanced the induction of LTP evoked by sub-threshold tetanic stimulation (20 pulses at 60 Hz) of the perforant pathway without affecting normal synaptic potentials. Intravenous injection of the compound (0.2-10.0 mg/kg) also enhanced the induction of LTP in a bell-shaped manner, whereas it had no effect on LTP evoked by supra-threshold tetanic stimulation (100 pulses at 100 Hz). Structurally related β-glucans did not mimic the lentinan-triggered enhancement of LTP. These results suggest that peripherally applied lentinan facilitates the synaptic efficacy of the dentate gyrus neurons in vivo.
Original language | English |
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Pages (from-to) | 139-142 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 314 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2001 Nov 16 |
Externally published | Yes |
Keywords
- Dentate gyrus
- Glucan
- In vivo recording
- Intravenous injection
- Lentinan
- Long-term potentiation
- Oral application
ASJC Scopus subject areas
- Neuroscience(all)