Abstract
We investigated the effects of oral and intravenous application of lentinan, a branched β-glucan, on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vivo. Oral administration of lentinan (200 mg/kg) enhanced the induction of LTP evoked by sub-threshold tetanic stimulation (20 pulses at 60 Hz) of the perforant pathway without affecting normal synaptic potentials. Intravenous injection of the compound (0.2-10.0 mg/kg) also enhanced the induction of LTP in a bell-shaped manner, whereas it had no effect on LTP evoked by supra-threshold tetanic stimulation (100 pulses at 100 Hz). Structurally related β-glucans did not mimic the lentinan-triggered enhancement of LTP. These results suggest that peripherally applied lentinan facilitates the synaptic efficacy of the dentate gyrus neurons in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 139-142 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 314 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 Nov 16 |
| Externally published | Yes |
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Keywords
- Dentate gyrus
- Glucan
- In vivo recording
- Intravenous injection
- Lentinan
- Long-term potentiation
- Oral application
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Systemic administration of lentinan, a branched β-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo. / Edagawa, Yoshikuni; Smriga, Miro; Nishiyama, Nobuyoshi; Saito, Hiroshi.
In: Neuroscience Letters, Vol. 314, No. 3, 16.11.2001, p. 139-142.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Systemic administration of lentinan, a branched β-glucan, enhances long-term potentiation in the rat dentate gyrus in vivo
AU - Edagawa, Yoshikuni
AU - Smriga, Miro
AU - Nishiyama, Nobuyoshi
AU - Saito, Hiroshi
PY - 2001/11/16
Y1 - 2001/11/16
N2 - We investigated the effects of oral and intravenous application of lentinan, a branched β-glucan, on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vivo. Oral administration of lentinan (200 mg/kg) enhanced the induction of LTP evoked by sub-threshold tetanic stimulation (20 pulses at 60 Hz) of the perforant pathway without affecting normal synaptic potentials. Intravenous injection of the compound (0.2-10.0 mg/kg) also enhanced the induction of LTP in a bell-shaped manner, whereas it had no effect on LTP evoked by supra-threshold tetanic stimulation (100 pulses at 100 Hz). Structurally related β-glucans did not mimic the lentinan-triggered enhancement of LTP. These results suggest that peripherally applied lentinan facilitates the synaptic efficacy of the dentate gyrus neurons in vivo.
AB - We investigated the effects of oral and intravenous application of lentinan, a branched β-glucan, on the induction of long-term potentiation (LTP) in the rat dentate gyrus in vivo. Oral administration of lentinan (200 mg/kg) enhanced the induction of LTP evoked by sub-threshold tetanic stimulation (20 pulses at 60 Hz) of the perforant pathway without affecting normal synaptic potentials. Intravenous injection of the compound (0.2-10.0 mg/kg) also enhanced the induction of LTP in a bell-shaped manner, whereas it had no effect on LTP evoked by supra-threshold tetanic stimulation (100 pulses at 100 Hz). Structurally related β-glucans did not mimic the lentinan-triggered enhancement of LTP. These results suggest that peripherally applied lentinan facilitates the synaptic efficacy of the dentate gyrus neurons in vivo.
KW - Dentate gyrus
KW - Glucan
KW - In vivo recording
KW - Intravenous injection
KW - Lentinan
KW - Long-term potentiation
KW - Oral application
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UR - http://www.scopus.com/inward/citedby.url?scp=0035900220&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(01)02301-1
DO - 10.1016/S0304-3940(01)02301-1
M3 - Article
C2 - 11704303
AN - SCOPUS:0035900220
VL - 314
SP - 139
EP - 142
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -