Abstract
We demonstrate that very stable hydrogels can be formed in aqueous potassium chloride solution by mixing a well-known gelator (guanosine, G) with a nongelator of similar structure (2′, 3′, 5′-tri-O- acetylguanosine, TAcG), and through a variety of characterization methods including rheology, small-angle neutron scattering, differential scanning calorimetry, and atomic force microscopy, we report substantial progress toward elucidating the factors that control the structure and stability of this fibrous gel system. The results suggest that the tailorability, long lifetime stability, and thermo-mechanical behavior of these gels derives from a reduction in the driving force toward crystallization with increased hydrophobic (TAcG) content, accompanied by a simultaneous decrease in fiber length and an increase in fiber width.
| Original language | English |
|---|---|
| Pages (from-to) | 8833-8840 |
| Number of pages | 8 |
| Journal | Langmuir |
| Volume | 25 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2009 Aug 4 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Electrochemistry
- Condensed Matter Physics
- Surfaces and Interfaces
- Materials Science(all)
- Spectroscopy
Cite this
Tailoring the properties of guanosine-based supramolecular hydrogels. / Buerkle, Lauren E.; Li, Zheng; Jamieson, Alexander M.; Rowan, Stuart J.
In: Langmuir, Vol. 25, No. 15, 04.08.2009, p. 8833-8840.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tailoring the properties of guanosine-based supramolecular hydrogels
AU - Buerkle, Lauren E.
AU - Li, Zheng
AU - Jamieson, Alexander M.
AU - Rowan, Stuart J.
PY - 2009/8/4
Y1 - 2009/8/4
N2 - We demonstrate that very stable hydrogels can be formed in aqueous potassium chloride solution by mixing a well-known gelator (guanosine, G) with a nongelator of similar structure (2′, 3′, 5′-tri-O- acetylguanosine, TAcG), and through a variety of characterization methods including rheology, small-angle neutron scattering, differential scanning calorimetry, and atomic force microscopy, we report substantial progress toward elucidating the factors that control the structure and stability of this fibrous gel system. The results suggest that the tailorability, long lifetime stability, and thermo-mechanical behavior of these gels derives from a reduction in the driving force toward crystallization with increased hydrophobic (TAcG) content, accompanied by a simultaneous decrease in fiber length and an increase in fiber width.
AB - We demonstrate that very stable hydrogels can be formed in aqueous potassium chloride solution by mixing a well-known gelator (guanosine, G) with a nongelator of similar structure (2′, 3′, 5′-tri-O- acetylguanosine, TAcG), and through a variety of characterization methods including rheology, small-angle neutron scattering, differential scanning calorimetry, and atomic force microscopy, we report substantial progress toward elucidating the factors that control the structure and stability of this fibrous gel system. The results suggest that the tailorability, long lifetime stability, and thermo-mechanical behavior of these gels derives from a reduction in the driving force toward crystallization with increased hydrophobic (TAcG) content, accompanied by a simultaneous decrease in fiber length and an increase in fiber width.
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UR - http://www.scopus.com/inward/citedby.url?scp=68149117578&partnerID=8YFLogxK
U2 - 10.1021/la900746w
DO - 10.1021/la900746w
M3 - Article
C2 - 19371040
AN - SCOPUS:68149117578
VL - 25
SP - 8833
EP - 8840
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 15
ER -