Taxonomic distribution of Streptomyces species capable of producing bioactive compounds among strains preserved at NITE/NBRC

Kozue Anzai, Michiyo Ohno, Takuji Nakashima, Natsumi Kuwahara, Rieko Suzuki, Tomohiko Tamura, Hisayuki Komaki, Shinji Miyadoh, Shigeaki Harayama, Katsuhiko Ando

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The taxonomic distribution of Streptomyces species capable of producing bioactive compounds was investigated. Nine hundred and six strains were tested for the following four biological activities: antimicrobial, anti-tyrosinase, antioxidant, and hemolytic. Approximately 30% of strains tested showed antimicrobial activities, except for anti-Escherichia coli activity, which was present in only a few strains, while the rates of positivity for the anti-tyrosinase, antioxidant, and hemolytic activities were much lower. The distribution of Streptomyces strains capable of producing bioactive compounds was analyzed by the taxonomy based on 16S rRNA gene sequences. Moreover, the strains of Streptomyces hygroscopicus tested were divided into two clades in the phylogenetic tree, and all of the strains belonging to one clade showed antibacterial and antifungal activities. For detection of polyenes, the UV-visible spectra of metabolic extracts in the strains showing antifungal activities were measured. It was suggested that Streptomyces strains produce universal active compounds under different growth conditions. Further information on the relationship between the microbial taxonomy and the bioactive compounds produced would be useful for the utilization of industrial microorganisms.

Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalApplied Microbiology and Biotechnology
Volume80
Issue number2
DOIs
Publication statusPublished - 2008 Aug
Externally publishedYes

Keywords

  • 16S rRNA
  • Bioactivity
  • Streptomyces
  • Taxonomy

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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