Tb 3+-enhanced potentiometric detection of single nucleotide polymorphism by field effect transistors

Jinping Wang, Kenya Ito, Takuya Nakanishi, Shigeki Kuroiwa, Tetsuya Osaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The use of Tb 3+ as a center ion and media to introduce more exogenously negative charges onto double-stranded DNA (dsDNA), can greatly enhance potentiometric signals produced by the shift of gate voltage of field effect transisitor (FET). Furthermore, different affinities of Tb 3+ to normal and mismatched dsDNAs amplified the signal difference between their detections, which can improve the discrimination of single nucleotide polymorphism.

Original languageEnglish
Pages (from-to)376-377
Number of pages2
JournalChemistry Letters
Volume38
Issue number4
DOIs
Publication statusPublished - 2009 Jul 20

ASJC Scopus subject areas

  • Chemistry(all)

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