Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue

Sachiko Nomura, Takashi Ichinose, Manabu Jinde, Yu Kawashima, Kaoru Tachiyashiki, Kazuhiko Imaizumi

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    Abstract

    The aim of the present study was to determine whether the antiobesity effects of tea catechins (TCs) are associated with the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT). Male Sprague-Dawley rats were fed a high-fat (HF; 35% fat) diet for 5 weeks, then divided into four groups and fed an HF, HF with 0.5% TC (HFTC), normal-fat (NF; 5% fat) or NF with 0.5% TC (NFTC) diet for 8 weeks. At the end of the experimental period, perirenal and epididymal white adipose tissues (WATs) and interscapular BAT were isolated. The NFTC group had significantly lower perirenal WAT weights than the NF group (NF: 12.7±0.53 g; NFTC: 10.2±0.43 g; P<.01), but the HF and HFTC groups did not differ significantly. TC intake had no effects on epididymal WAT weights. The NFTC and HFTC groups had significantly lower BAT weights than the NF and HF groups, respectively. The NFTC group had significantly higher UCP1 mRNA levels in BAT than the NF group (NF: 0.35±0.02; NFTC: 0.60±0.11; P<.05), but the HF and HFTC groups did not differ significantly. Thus, TC intake in the context of the NF diet reduced perirenal WAT weight and up-regulated UCP1 mRNA expression in BAT. These results suggest that the suppressive effect of TC on body fat accumulation is associated with UCP1 expression in BAT.

    Original languageEnglish
    Pages (from-to)840-847
    Number of pages8
    JournalJournal of Nutritional Biochemistry
    Volume19
    Issue number12
    DOIs
    Publication statusPublished - 2008 Dec

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    Keywords

    • Brown adipose tissue
    • High-fat diet
    • Normal-fat diet
    • Tea catechins
    • Uncoupling protein 1

    ASJC Scopus subject areas

    • Biochemistry
    • Clinical Biochemistry
    • Molecular Biology
    • Endocrinology, Diabetes and Metabolism
    • Nutrition and Dietetics

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