Technical evaluation of dialysate flow in a hollow-fiber dialyzer

Kei Ishiwata, Kenichiro Yamamoto, Fukashi Kohori, Kiyotaka Sakai, Makoto Fukuda, Tatsuo Hiyoshi

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    In a hollow-fiber dialyzer, uremic toxins are removed by diffusion and convection, which are influenced by the dialysate flow patterns in the dialyzer. Recently available high-performance dialyzers have complicated dialysate flow patterns, because both positive filtration and negative filtration occur. The objective of the present study was to evaluate dialysate flow in high-performance dialyzers experimentally. Glass-coated 0.1 mmφ platinum electrodes were used for the electrode counter and the working electrode. A counter electrode was placed at the inlet of the dialyzer, and working electrodes were placed at 20 different positions. A voltage of 0.5V was applied between the counter and the working electrodes with a potentiostat, and after the dialyzer was filled with water purified by reverse osmosis, 0.9% NaCl solution was caused to flow. The time at which the 0.9% NaCl solution reached each working electrode from the counter electrode was then measured at a dialysate-side flow rate of 300ml/min and blood-side flow rates of 0 and 200 ml/min. It was found that in dialyzers with high permeability to pure water, dialysate flow was affected by both positive and negative filtration. A comparison was then made between the experimental results and the results of simulation by the finite element method; at positions at which positive and negative filtration occurred, good agreement was obtained. This method makes possible the experimental evaluation of dialysate flow in a high-performance dialyzer in which positive and negative filtration occur.

    Original languageEnglish
    Pages (from-to)251-256
    Number of pages6
    JournalJournal of Artificial Organs
    Volume5
    Issue number4
    DOIs
    Publication statusPublished - 2002

    Fingerprint

    Dialysis Solutions
    Electrodes
    Fibers
    Flow patterns
    Flow rate
    Osmosis
    Convection
    Water
    Reverse osmosis
    Platinum
    Glass
    Permeability
    Blood
    Finite element method
    Electric potential

    Keywords

    • Dialysate flow
    • Filtration
    • Hollow-fiber dialyzer
    • Pt electrode
    • Simulation

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Technical evaluation of dialysate flow in a hollow-fiber dialyzer. / Ishiwata, Kei; Yamamoto, Kenichiro; Kohori, Fukashi; Sakai, Kiyotaka; Fukuda, Makoto; Hiyoshi, Tatsuo.

    In: Journal of Artificial Organs, Vol. 5, No. 4, 2002, p. 251-256.

    Research output: Contribution to journalArticle

    Ishiwata, K, Yamamoto, K, Kohori, F, Sakai, K, Fukuda, M & Hiyoshi, T 2002, 'Technical evaluation of dialysate flow in a hollow-fiber dialyzer', Journal of Artificial Organs, vol. 5, no. 4, pp. 251-256. https://doi.org/10.1007/s100470200047
    Ishiwata, Kei ; Yamamoto, Kenichiro ; Kohori, Fukashi ; Sakai, Kiyotaka ; Fukuda, Makoto ; Hiyoshi, Tatsuo. / Technical evaluation of dialysate flow in a hollow-fiber dialyzer. In: Journal of Artificial Organs. 2002 ; Vol. 5, No. 4. pp. 251-256.
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