Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats

Zsolt Radak, A. W. Taylor, M. Sasvari, H. Ohno, B. Horkay, J. Furesz, D. Gaal, T. Kanel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Telomerase is a specialized ribonucleoprotein enzyme complex which prevents the loss of the telomere. The activity of telomerase can be up- and down-regulated by various oxidative stresses but the effect of physical exercise is not known, whereas the modifying effect of cancer on telomerase activity is well documented. In the first study, we investigated the effect of mild and strenuous exercise training on telomerase activity, assessed by a PCR ELISA kit. No alteration in telomerase activity was detected. In the second investigation, solid sarcoma cells were transplanted to control, exercise trained or exercise trained and still exercising mice. On the 16th day after the transplantation, the size of tumors in the exercise trained group was 72% and in the exercising group 57% (P < 0.05) of that in the controls. Telomerase activity and 8-hydroxy-2′-deoxyguanosine levels in the liver were not significantly altered by exercise and/or sarcoma. We conclude that mild and strenuous exercise training does not significantly affect the activity of telomerase in the systems studied. Exercise training during sarcoma significantly retards the development of tumors and could possibly serve as a positive adjunct to treatment.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalRedox Report
Volume6
Issue number2
DOIs
Publication statusPublished - 2001 Jun 21
Externally publishedYes

Fingerprint

Telomerase
Sarcoma
Liver
Muscle
Rats
Skeletal Muscle
Exercise
Tumors
Neoplasms
Ribonucleoproteins
Oxidative stress
Telomere
Oxidative Stress
Transplantation
Enzyme-Linked Immunosorbent Assay
Polymerase Chain Reaction
Enzymes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Radak, Z., Taylor, A. W., Sasvari, M., Ohno, H., Horkay, B., Furesz, J., ... Kanel, T. (2001). Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats. Redox Report, 6(2), 99-103. https://doi.org/10.1179/135100001101536102

Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats. / Radak, Zsolt; Taylor, A. W.; Sasvari, M.; Ohno, H.; Horkay, B.; Furesz, J.; Gaal, D.; Kanel, T.

In: Redox Report, Vol. 6, No. 2, 21.06.2001, p. 99-103.

Research output: Contribution to journalArticle

Radak, Z, Taylor, AW, Sasvari, M, Ohno, H, Horkay, B, Furesz, J, Gaal, D & Kanel, T 2001, 'Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats', Redox Report, vol. 6, no. 2, pp. 99-103. https://doi.org/10.1179/135100001101536102
Radak, Zsolt ; Taylor, A. W. ; Sasvari, M. ; Ohno, H. ; Horkay, B. ; Furesz, J. ; Gaal, D. ; Kanel, T. / Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats. In: Redox Report. 2001 ; Vol. 6, No. 2. pp. 99-103.
@article{59777b8573bc49248279fe368b959f9b,
title = "Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats",
abstract = "Telomerase is a specialized ribonucleoprotein enzyme complex which prevents the loss of the telomere. The activity of telomerase can be up- and down-regulated by various oxidative stresses but the effect of physical exercise is not known, whereas the modifying effect of cancer on telomerase activity is well documented. In the first study, we investigated the effect of mild and strenuous exercise training on telomerase activity, assessed by a PCR ELISA kit. No alteration in telomerase activity was detected. In the second investigation, solid sarcoma cells were transplanted to control, exercise trained or exercise trained and still exercising mice. On the 16th day after the transplantation, the size of tumors in the exercise trained group was 72{\%} and in the exercising group 57{\%} (P < 0.05) of that in the controls. Telomerase activity and 8-hydroxy-2′-deoxyguanosine levels in the liver were not significantly altered by exercise and/or sarcoma. We conclude that mild and strenuous exercise training does not significantly affect the activity of telomerase in the systems studied. Exercise training during sarcoma significantly retards the development of tumors and could possibly serve as a positive adjunct to treatment.",
author = "Zsolt Radak and Taylor, {A. W.} and M. Sasvari and H. Ohno and B. Horkay and J. Furesz and D. Gaal and T. Kanel",
year = "2001",
month = "6",
day = "21",
doi = "10.1179/135100001101536102",
language = "English",
volume = "6",
pages = "99--103",
journal = "Redox Report",
issn = "1351-0002",
publisher = "Maney Publishing",
number = "2",

}

TY - JOUR

T1 - Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats

AU - Radak, Zsolt

AU - Taylor, A. W.

AU - Sasvari, M.

AU - Ohno, H.

AU - Horkay, B.

AU - Furesz, J.

AU - Gaal, D.

AU - Kanel, T.

PY - 2001/6/21

Y1 - 2001/6/21

N2 - Telomerase is a specialized ribonucleoprotein enzyme complex which prevents the loss of the telomere. The activity of telomerase can be up- and down-regulated by various oxidative stresses but the effect of physical exercise is not known, whereas the modifying effect of cancer on telomerase activity is well documented. In the first study, we investigated the effect of mild and strenuous exercise training on telomerase activity, assessed by a PCR ELISA kit. No alteration in telomerase activity was detected. In the second investigation, solid sarcoma cells were transplanted to control, exercise trained or exercise trained and still exercising mice. On the 16th day after the transplantation, the size of tumors in the exercise trained group was 72% and in the exercising group 57% (P < 0.05) of that in the controls. Telomerase activity and 8-hydroxy-2′-deoxyguanosine levels in the liver were not significantly altered by exercise and/or sarcoma. We conclude that mild and strenuous exercise training does not significantly affect the activity of telomerase in the systems studied. Exercise training during sarcoma significantly retards the development of tumors and could possibly serve as a positive adjunct to treatment.

AB - Telomerase is a specialized ribonucleoprotein enzyme complex which prevents the loss of the telomere. The activity of telomerase can be up- and down-regulated by various oxidative stresses but the effect of physical exercise is not known, whereas the modifying effect of cancer on telomerase activity is well documented. In the first study, we investigated the effect of mild and strenuous exercise training on telomerase activity, assessed by a PCR ELISA kit. No alteration in telomerase activity was detected. In the second investigation, solid sarcoma cells were transplanted to control, exercise trained or exercise trained and still exercising mice. On the 16th day after the transplantation, the size of tumors in the exercise trained group was 72% and in the exercising group 57% (P < 0.05) of that in the controls. Telomerase activity and 8-hydroxy-2′-deoxyguanosine levels in the liver were not significantly altered by exercise and/or sarcoma. We conclude that mild and strenuous exercise training does not significantly affect the activity of telomerase in the systems studied. Exercise training during sarcoma significantly retards the development of tumors and could possibly serve as a positive adjunct to treatment.

UR - http://www.scopus.com/inward/record.url?scp=0034988564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034988564&partnerID=8YFLogxK

U2 - 10.1179/135100001101536102

DO - 10.1179/135100001101536102

M3 - Article

C2 - 11450989

AN - SCOPUS:0034988564

VL - 6

SP - 99

EP - 103

JO - Redox Report

JF - Redox Report

SN - 1351-0002

IS - 2

ER -