The activity of isolated neurons and the modulatory state of an isolated nervous system represent a recent behavioural state

Varvara E. Dyakonova, Laszlo Hernadi, Etsuro Ito, Taisia L. Dyakonova, Ilya A. Chistopolsky, Igor S. Zakharov, Dmitri A. Sakharov

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Behavioural/motivational state is known to influence nearly all aspects of physiology and behaviour. The cellular basis of behavioural state control is only partially understood.Our investigation, performed on the pond snail Lymnaea stagnalis whose nervous systemis useful for work on completely isolated neurons, provided several results related to this problem. First,we demonstrated that the behavioural state can produce long-term changes in individual neurons that persist even after neuron isolation from the nervous system. Specifically, we found that pedal serotonergic neurons that control locomotion show higher activity and lower membrane potential after being isolated from the nervous systems of hungry animals. Second, we showed that the modulatory state (the chemical neuroactive microenvironment of the central ganglia) changes in accordance with the nutritional state of an animal and produces predicted changes in single isolated locomotor neurons. Third,we report that observedhunger-inducedeffects canbeexplained by the increased synthesis of serotonin in pedal serotonergic neurons, which has an impact on the electrical activity of isolated serotonergic neurons and the intensity of extrasynaptic serotonin release from the pedal ganglia.

Original languageEnglish
Pages (from-to)1151-1158
Number of pages8
JournalJournal of Experimental Biology
Volume218
Issue number8
DOIs
Publication statusPublished - 2015 Apr 15

Keywords

  • Extrasynaptic release
  • Lymnaea stagnalis
  • Neuromodulation
  • Neurotransmitter synthesis
  • Serotonergic neuron
  • Volume transmission

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

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  • Cite this

    Dyakonova, V. E., Hernadi, L., Ito, E., Dyakonova, T. L., Chistopolsky, I. A., Zakharov, I. S., & Sakharov, D. A. (2015). The activity of isolated neurons and the modulatory state of an isolated nervous system represent a recent behavioural state. Journal of Experimental Biology, 218(8), 1151-1158. https://doi.org/10.1242/jeb.111930