The activity of isolated snail neurons controlling locomotion is affected by glucose

Varvara Dyakonova, László Hernádi, Etsuro Ito, Taisia Dyakonova, Igor Zakharov, Dmitri Sakharov

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The involvement of serotonin in mediating hunger-related changes in behavioral state has been described in many invertebrates. However, the mechanisms by which hunger signals to serotonergic cells remain unknown. We tested the hypothesis that serotonergic neurons can directly sense the concentration of glucose, a metabolic indicator of nutritional state. In the snail Lymnaea stagnalis, we demonstrate that completely isolated pedal serotonergic neurons that control locomotion changed their biophysical characteristics in response to glucose application by lowering membrane potential and decreasing the firing rate. Additionally, the excitatory response of the isolated serotonergic neurons to the neuroactive microenvironment of the pedal ganglia was significantly lowered by glucose application. Because hunger has been reported to increase the activity of select neurons and their responses to the pedal ganglia microenvironment, these responses to glucose are in accordance with the hypothesis that direct glucose signaling is involved in the mediation of the hunger-related behavioral state.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalBiophysics (Japan)
Volume11
DOIs
Publication statusPublished - 2015
Externally publishedYes

Fingerprint

Snails
Locomotion
Hunger
Serotonergic Neurons
Neurons
Glucose
Foot
Ganglia
Lymnaea
Invertebrates
Membrane Potentials
Serotonin

Keywords

  • Behavioral state
  • Extrasynaptic release
  • Lymnaea stagnalis
  • Serotonergic neuron
  • Volume transmission

ASJC Scopus subject areas

  • Biophysics

Cite this

The activity of isolated snail neurons controlling locomotion is affected by glucose. / Dyakonova, Varvara; Hernádi, László; Ito, Etsuro; Dyakonova, Taisia; Zakharov, Igor; Sakharov, Dmitri.

In: Biophysics (Japan), Vol. 11, 2015, p. 55-60.

Research output: Contribution to journalArticle

Dyakonova, Varvara ; Hernádi, László ; Ito, Etsuro ; Dyakonova, Taisia ; Zakharov, Igor ; Sakharov, Dmitri. / The activity of isolated snail neurons controlling locomotion is affected by glucose. In: Biophysics (Japan). 2015 ; Vol. 11. pp. 55-60.
@article{841288d77e31443fa164b16dec7966c3,
title = "The activity of isolated snail neurons controlling locomotion is affected by glucose",
abstract = "The involvement of serotonin in mediating hunger-related changes in behavioral state has been described in many invertebrates. However, the mechanisms by which hunger signals to serotonergic cells remain unknown. We tested the hypothesis that serotonergic neurons can directly sense the concentration of glucose, a metabolic indicator of nutritional state. In the snail Lymnaea stagnalis, we demonstrate that completely isolated pedal serotonergic neurons that control locomotion changed their biophysical characteristics in response to glucose application by lowering membrane potential and decreasing the firing rate. Additionally, the excitatory response of the isolated serotonergic neurons to the neuroactive microenvironment of the pedal ganglia was significantly lowered by glucose application. Because hunger has been reported to increase the activity of select neurons and their responses to the pedal ganglia microenvironment, these responses to glucose are in accordance with the hypothesis that direct glucose signaling is involved in the mediation of the hunger-related behavioral state.",
keywords = "Behavioral state, Extrasynaptic release, Lymnaea stagnalis, Serotonergic neuron, Volume transmission",
author = "Varvara Dyakonova and L{\'a}szl{\'o} Hern{\'a}di and Etsuro Ito and Taisia Dyakonova and Igor Zakharov and Dmitri Sakharov",
year = "2015",
doi = "10.2142/biophysics.11.55",
language = "English",
volume = "11",
pages = "55--60",
journal = "Biophysics (Japan)",
issn = "1349-2942",
publisher = "Biophysical Society of Japan",

}

TY - JOUR

T1 - The activity of isolated snail neurons controlling locomotion is affected by glucose

AU - Dyakonova, Varvara

AU - Hernádi, László

AU - Ito, Etsuro

AU - Dyakonova, Taisia

AU - Zakharov, Igor

AU - Sakharov, Dmitri

PY - 2015

Y1 - 2015

N2 - The involvement of serotonin in mediating hunger-related changes in behavioral state has been described in many invertebrates. However, the mechanisms by which hunger signals to serotonergic cells remain unknown. We tested the hypothesis that serotonergic neurons can directly sense the concentration of glucose, a metabolic indicator of nutritional state. In the snail Lymnaea stagnalis, we demonstrate that completely isolated pedal serotonergic neurons that control locomotion changed their biophysical characteristics in response to glucose application by lowering membrane potential and decreasing the firing rate. Additionally, the excitatory response of the isolated serotonergic neurons to the neuroactive microenvironment of the pedal ganglia was significantly lowered by glucose application. Because hunger has been reported to increase the activity of select neurons and their responses to the pedal ganglia microenvironment, these responses to glucose are in accordance with the hypothesis that direct glucose signaling is involved in the mediation of the hunger-related behavioral state.

AB - The involvement of serotonin in mediating hunger-related changes in behavioral state has been described in many invertebrates. However, the mechanisms by which hunger signals to serotonergic cells remain unknown. We tested the hypothesis that serotonergic neurons can directly sense the concentration of glucose, a metabolic indicator of nutritional state. In the snail Lymnaea stagnalis, we demonstrate that completely isolated pedal serotonergic neurons that control locomotion changed their biophysical characteristics in response to glucose application by lowering membrane potential and decreasing the firing rate. Additionally, the excitatory response of the isolated serotonergic neurons to the neuroactive microenvironment of the pedal ganglia was significantly lowered by glucose application. Because hunger has been reported to increase the activity of select neurons and their responses to the pedal ganglia microenvironment, these responses to glucose are in accordance with the hypothesis that direct glucose signaling is involved in the mediation of the hunger-related behavioral state.

KW - Behavioral state

KW - Extrasynaptic release

KW - Lymnaea stagnalis

KW - Serotonergic neuron

KW - Volume transmission

UR - http://www.scopus.com/inward/record.url?scp=84924101605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924101605&partnerID=8YFLogxK

U2 - 10.2142/biophysics.11.55

DO - 10.2142/biophysics.11.55

M3 - Article

VL - 11

SP - 55

EP - 60

JO - Biophysics (Japan)

JF - Biophysics (Japan)

SN - 1349-2942

ER -