The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease

Michael Gleeson; Nicolette C. Bishop; David J. Stensel; Martin R. Lindley; Sarabjit S. Mastana; Myra A. Nimmo

doi:10.1038/nri3041

The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease

Michael Gleeson^*, Nicolette C. Bishop, David J. Stensel, Martin R. Lindley, Sarabjit S. Mastana, Myra A. Nimmo

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1299 Citations (Scopus)

Abstract

Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise both acute and chronic exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.

Original language	English
Pages (from-to)	607-610
Number of pages	4
Journal	Nature Reviews Immunology
Volume	11
Issue number	9
DOIs	https://doi.org/10.1038/nri3041
Publication status	Published - 2011 Sept
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease

Abstract

ASJC Scopus subject areas

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