The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease

Michael Gleeson*, Nicolette C. Bishop, David J. Stensel, Martin R. Lindley, Sarabjit S. Mastana, Myra A. Nimmo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1138 Citations (Scopus)

Abstract

Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise both acute and chronic exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.

Original languageEnglish
Pages (from-to)607-610
Number of pages4
JournalNature Reviews Immunology
Volume11
Issue number9
DOIs
Publication statusPublished - 2011 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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