TY - JOUR
T1 - The Association of Fit-Fat Index with Incident Diabetes in, Japanese Men
T2 - A Prospective Cohort Study
AU - Sloan, Robert A.
AU - Sawada, Susumu S.
AU - I-Min, Lee
AU - Gando, Yuko
AU - Kawakami, Ryoko
AU - Okamoto, Takashi
AU - Tsukamoto, Koji
AU - Miyachi, Motohiko
N1 - Funding Information:
?Kagoshima University, Graduate Medical and Dental School, Department of Psychosomatic Internal Medicine, Kagoshima, Japan. ?National Institutes of Biomedical Innovation, Health and Nutrition, Department of Health Promotion and Exercise, Tokyo, Japan. ?Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA. ?Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA. ?Waseda University, Faculty of Sport Sciences, Saitama, Japan. ?Tokyo Gas Co., Ltd., Health Promotion Center, Tokyo, Japan. Correspondence and requests for materials should be addressed to R.A.S. (email: rsloan@m.kufm.kagoshima-u.ac.jp)
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Type 2 diabetes is increasing globally and in Asia. The purpose of this study was to examine the association of a fit-fat index (FFI) with diabetes incidence among, Japanese men. In total 5,014 men aged 18-64 years old, who had an annual health check up with no history of major chronic disease at baseline from 2002 to 2009 were observed. CRF was estimated via cycle ergometry. Overall, 7.6% of the men developed diabetes. The mean follow-up period was 5.3 years. Hazard ratios, 95% confidence intervals and P trend for diabetes incidence were obtained using the Cox proportional hazards model while adjusting for confounding variables. High FFI demonstrated lower risk 0.54 (0.36-0.82) compared to low BMI 0.63 (0.44-0.90), low WHtR 0.64 (0.41-1.02), and High CRF 0.72 (0.51-1.03). FFI showed a marginally stronger dose response relationship across quartiles (P (trend) =0.001) compared to BMI (P (trend) =0.002), WHtR (P (trend) =0.055), and CRF (P (trend) =0.005). Overall, both fitness and fatness play independent roles in determining diabetes incidence in, Japanese men. FFI may be a more advantageous physical fitness measure because it can account for changes in fitness and/or fatness.
AB - Type 2 diabetes is increasing globally and in Asia. The purpose of this study was to examine the association of a fit-fat index (FFI) with diabetes incidence among, Japanese men. In total 5,014 men aged 18-64 years old, who had an annual health check up with no history of major chronic disease at baseline from 2002 to 2009 were observed. CRF was estimated via cycle ergometry. Overall, 7.6% of the men developed diabetes. The mean follow-up period was 5.3 years. Hazard ratios, 95% confidence intervals and P trend for diabetes incidence were obtained using the Cox proportional hazards model while adjusting for confounding variables. High FFI demonstrated lower risk 0.54 (0.36-0.82) compared to low BMI 0.63 (0.44-0.90), low WHtR 0.64 (0.41-1.02), and High CRF 0.72 (0.51-1.03). FFI showed a marginally stronger dose response relationship across quartiles (P (trend) =0.001) compared to BMI (P (trend) =0.002), WHtR (P (trend) =0.055), and CRF (P (trend) =0.005). Overall, both fitness and fatness play independent roles in determining diabetes incidence in, Japanese men. FFI may be a more advantageous physical fitness measure because it can account for changes in fitness and/or fatness.
UR - http://www.scopus.com/inward/record.url?scp=85043505843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043505843&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-18898-3
DO - 10.1038/s41598-017-18898-3
M3 - Article
C2 - 29330373
AN - SCOPUS:85043505843
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 569
ER -