The caudal periaqueductal gray participates in the activation of brown adipose tissue in rats

Xiao Ming Chen, Maiko Nishi, Aki Taniguchi, Kei Nagashima, Masaaki Shibata, Kazuyuki Kanosue

Research output: Contribution to journalArticle

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To investigate the involvement of the periaqueductal gray (PAG) in the control of non-shivering thermogenesis, we tested the effects of electrical or chemical stimulation of the PAG on thermogenesis of brown adipose tissue (BAT) in urethane anesthetized rats. Electrical stimulation (0.1 mA, 33 Hz, 0.5 ms) or application of D,L-homocysteic acid (0.5 mM, 0.3 μl) into the lateral region of the caudal PAG (cPAG) elicited BAT thermogenesis, measured as a rise in the local temperature of interscapular BAT. These results suggest that neurons in the cPAG send excitatory efferent signals for BAT thermogenesis.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2002 Oct 4



  • Non-shivering thermogenesis
  • Periaqueductal gray
  • Thermoregulation

ASJC Scopus subject areas

  • Neuroscience(all)

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