The complete genomic sequence of Niocardia farcinica IFM 10152

Jun Ishikawa; Atsushi Yamashita; Yuzuru Mikami; Yasutaka Hoshino; Haruyo Kurita; Kunimoto Hotta; Tadayoshi Shiba; Masahira Hattori

doi:10.1073/pnas.0406410101

The complete genomic sequence of Niocardia farcinica IFM 10152

Jun Ishikawa^*, Atsushi Yamashita, Yuzuru Mikami, Yasutaka Hoshino, Haruyo Kurita, Kunimoto Hotta, Tadayoshi Shiba, Masahira Hattori

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

233 Citations (Scopus)

Abstract

We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNFl) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.

Original language	English
Pages (from-to)	14925-14930
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	101
Issue number	41
DOIs	https://doi.org/10.1073/pnas.0406410101
Publication status	Published - 2004 Oct 12
Externally published	Yes

ASJC Scopus subject areas

Genetics
General

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abstract = "We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNFl) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.",

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AU - Ishikawa, Jun

AU - Yamashita, Atsushi

AU - Mikami, Yuzuru

AU - Hoshino, Yasutaka

AU - Kurita, Haruyo

AU - Hotta, Kunimoto

AU - Shiba, Tadayoshi

AU - Hattori, Masahira

PY - 2004/10/12

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The complete genomic sequence of Niocardia farcinica IFM 10152

Abstract

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