The cortisol awakening response and autonomic nervous system activity during nocturnal and early morning periods

Shuhei Izawa, Nagisa Sugaya, Ryuichiro Yamamoto, Namiko Ogawa, Shinobu Nomura

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    The current study focuses on autonomic nervous system activity during sleep as a physiological aspect of sleep quality, and investigated the associations between the cortisol awakening response (CAR) and autonomic activity during sleep and after awakening. Ambulatory electrocardiograms were obtained from 20 participants, who also provided saliva samples (at the time of awakening, and 30, 45, and 60 min after awakening) and rated the subjective quality of their sleep at home. Autonomic activity was assessed with the Lorenz plot indices, cardiac sympathetic index (CSI) and cardiac vagal index. Total salivary cortisol secretion after awakening was calculated as area under the curve with respect to ground (AUCG) and increase (AUCI). After controlling for confounding factors, including sleep duration and awakening time, cortisol AUCG and AUCI were both found to be negatively correlated with CSI during the 30 min before and after awakening: before (r = -0.526 and -0.601 respectively) and after (r = -0.540 and -0.493 respectively). Self-reported sleep quality was not associated with the CAR. These results suggest that the CAR is negatively affected by basal sympathetic activity immediately before and after awakening, but not affected by subjective sleep quality. Physiological arousals around the time of awakening might inhibit the CAR.

    Original languageEnglish
    Pages (from-to)130-134
    Number of pages5
    JournalActivitas Nervosa Superior Rediviva
    Volume52
    Issue number2
    Publication statusPublished - 2010

    Fingerprint

    Autonomic Nervous System
    Hydrocortisone
    Sleep
    Arousal
    Saliva
    Area Under Curve
    Electrocardiography

    Keywords

    • Ambulatory electrocardiograms
    • Autonomic nervous system activity
    • Awakening
    • Cortisol
    • Sleep quality

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    The cortisol awakening response and autonomic nervous system activity during nocturnal and early morning periods. / Izawa, Shuhei; Sugaya, Nagisa; Yamamoto, Ryuichiro; Ogawa, Namiko; Nomura, Shinobu.

    In: Activitas Nervosa Superior Rediviva, Vol. 52, No. 2, 2010, p. 130-134.

    Research output: Contribution to journalArticle

    Izawa, Shuhei ; Sugaya, Nagisa ; Yamamoto, Ryuichiro ; Ogawa, Namiko ; Nomura, Shinobu. / The cortisol awakening response and autonomic nervous system activity during nocturnal and early morning periods. In: Activitas Nervosa Superior Rediviva. 2010 ; Vol. 52, No. 2. pp. 130-134.
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