The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming

Kouji Tanaka, Hayato Yamana

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Estimating mutual interactions of genetic networks is mainly to infer the mutual control relationships from multiple genes from the gene expression data. Such correlations are typically expressible in the form of nonlinear simultaneous differential equations. However, most work to date has employed S-systems as an expression of such differential equations, allowing only rough approximations of mass actions, and as such it was difficult to determine the actual correlations between the genes. Instead, we formulate the mutual interactions as actual simultaneous partial differential equations, and automatically determine its structure and coefficients using genetic programming (GP) from a given data series. Parallel implementation of the scheme in a Grid environment using our Jojo Grid programming system for Java has resulted in precise determination of the equations in many cases within some reasonable time.

    Original languageEnglish
    Title of host publicationWMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.
    Pages13-18
    Number of pages6
    Volume4
    Publication statusPublished - 2007
    Event11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Orlando, FL
    Duration: 2007 Jul 82007 Jul 11

    Other

    Other11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007
    CityOrlando, FL
    Period07/7/807/7/11

    Fingerprint

    Genetic programming
    Differential equations
    Genes
    Computer systems programming
    Gene expression
    Partial differential equations

    ASJC Scopus subject areas

    • Artificial Intelligence
    • Information Systems

    Cite this

    Tanaka, K., & Yamana, H. (2007). The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming. In WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc. (Vol. 4, pp. 13-18)

    The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming. / Tanaka, Kouji; Yamana, Hayato.

    WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. Vol. 4 2007. p. 13-18.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Tanaka, K & Yamana, H 2007, The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming. in WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. vol. 4, pp. 13-18, 11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007, Orlando, FL, 07/7/8.
    Tanaka K, Yamana H. The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming. In WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. Vol. 4. 2007. p. 13-18
    Tanaka, Kouji ; Yamana, Hayato. / The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming. WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.. Vol. 4 2007. pp. 13-18
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