The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming

Kouji Tanaka, Hayato Yamana

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Estimating mutual interactions of genetic networks is mainly to infer the mutual control relationships from multiple genes from the gene expression data. Such correlations are typically expressible in the form of nonlinear simultaneous differential equations. However, most work to date has employed S-systems as an expression of such differential equations, allowing only rough approximations of mass actions, and as such it was difficult to determine the actual correlations between the genes. Instead, we formulate the mutual interactions as actual simultaneous partial differential equations, and automatically determine its structure and coefficients using genetic programming (GP) from a given data series. Parallel implementation of the scheme in a Grid environment using our Jojo Grid programming system for Java has resulted in precise determination of the equations in many cases within some reasonable time.

Original languageEnglish
Title of host publicationWMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.
Pages13-18
Number of pages6
Publication statusPublished - 2007 Dec 1
Event11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Orlando, FL, United States
Duration: 2007 Jul 82007 Jul 11

Publication series

NameWMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.
Volume4

Conference

Conference11th World Multi-Conference on Systemics, Cybernetics and Informatics, WMSCI 2007, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007
CountryUnited States
CityOrlando, FL
Period07/7/807/7/11

ASJC Scopus subject areas

  • Artificial Intelligence
  • Information Systems

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    Tanaka, K., & Yamana, H. (2007). The development and evaluation of a prototype system for the inference of genetic networks based on genetic programming. In WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc. (pp. 13-18). (WMSCI 2007 - The 11th World Multi-Conference on Systemics, Cybernetics and Informatics, Jointly with the 13th International Conference on Information Systems Analysis and Synthesis, ISAS 2007 - Proc.; Vol. 4).