The effect of food intake on pharmacokinetics of lansoprazole OD tablet

Yasuhiro Fujiwara, Hirotoshi Okazaki, Akira Higashimori, Naoko Sugita, Masako Tanaka, Taishi Sakai, Masanori Kobayashi, Masaki Shindo, Hirohisa Machida, Tetsuya Tanigawa, Hirokazu Yamagami, Kenji Watanabe, Toshio Watanabe, Kazunari Tominaga, Tetsuo Arakawa

Research output: Contribution to journalArticle

Abstract

Background and Objective: Insufficient absorption of proton pump inhibitor (PPI) might be a treatment refractory factor, however, limited evidences were reported on the effect of pharmacokinetic parameter of PPI when taking the drug after food intake. The aim of this study was to compare the pharmacokinetic parameter of lansoprazole orally dispersing (LPZ-OD) tablet between conditions of taking the drug after food intake and under fasting conditions. Methods: Nine healthy male volunteers took LPZ-OD (Takepron® OD) tablet 30 mg either 15 minutes after breakfast or under fasting conditions in a cross-over fashion. The wash-out period of each term was 7 days at least. Blood samples were taken for measurement of pharmacokinetic parameter of LPZ. Results: The AUC 0-inf, C max, and t max in the drug administration after food intake were significantly decreased than that of fasting conditions. The respective AUC 0-inf was 4512±1958 ng·h/mL and 3083±1688 ng·h/mL (p<0.05), C max was 1275±528 ng/mL and 624±307 ng/mL (p<0.05), and t max was 2.0±0.8 h and 3.3±1.0 h (p<0.05). No significant difference in t 1/2 was observed. Conclusions: This study suggested food intake may affect pharmacokinetic parameters (AUC 0-inf, C max, and t max) of LPZ-OD tablet.

Original languageEnglish
Pages (from-to)961-966
Number of pages6
JournalJapanese Pharmacology and Therapeutics
Volume39
Issue number11
Publication statusPublished - 2011 Nov 20
Externally publishedYes

Fingerprint

Lansoprazole
Tablets
Pharmacokinetics
Eating
Area Under Curve
Fasting
Proton Pump Inhibitors
Pharmaceutical Preparations
Breakfast
Healthy Volunteers

Keywords

  • Food intake
  • Lansoprazole
  • Pharmacokinetics
  • Resistance

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Fujiwara, Y., Okazaki, H., Higashimori, A., Sugita, N., Tanaka, M., Sakai, T., ... Arakawa, T. (2011). The effect of food intake on pharmacokinetics of lansoprazole OD tablet. Japanese Pharmacology and Therapeutics, 39(11), 961-966.

The effect of food intake on pharmacokinetics of lansoprazole OD tablet. / Fujiwara, Yasuhiro; Okazaki, Hirotoshi; Higashimori, Akira; Sugita, Naoko; Tanaka, Masako; Sakai, Taishi; Kobayashi, Masanori; Shindo, Masaki; Machida, Hirohisa; Tanigawa, Tetsuya; Yamagami, Hirokazu; Watanabe, Kenji; Watanabe, Toshio; Tominaga, Kazunari; Arakawa, Tetsuo.

In: Japanese Pharmacology and Therapeutics, Vol. 39, No. 11, 20.11.2011, p. 961-966.

Research output: Contribution to journalArticle

Fujiwara, Y, Okazaki, H, Higashimori, A, Sugita, N, Tanaka, M, Sakai, T, Kobayashi, M, Shindo, M, Machida, H, Tanigawa, T, Yamagami, H, Watanabe, K, Watanabe, T, Tominaga, K & Arakawa, T 2011, 'The effect of food intake on pharmacokinetics of lansoprazole OD tablet', Japanese Pharmacology and Therapeutics, vol. 39, no. 11, pp. 961-966.
Fujiwara Y, Okazaki H, Higashimori A, Sugita N, Tanaka M, Sakai T et al. The effect of food intake on pharmacokinetics of lansoprazole OD tablet. Japanese Pharmacology and Therapeutics. 2011 Nov 20;39(11):961-966.
Fujiwara, Yasuhiro ; Okazaki, Hirotoshi ; Higashimori, Akira ; Sugita, Naoko ; Tanaka, Masako ; Sakai, Taishi ; Kobayashi, Masanori ; Shindo, Masaki ; Machida, Hirohisa ; Tanigawa, Tetsuya ; Yamagami, Hirokazu ; Watanabe, Kenji ; Watanabe, Toshio ; Tominaga, Kazunari ; Arakawa, Tetsuo. / The effect of food intake on pharmacokinetics of lansoprazole OD tablet. In: Japanese Pharmacology and Therapeutics. 2011 ; Vol. 39, No. 11. pp. 961-966.
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AU - Tanaka, Masako

AU - Sakai, Taishi

AU - Kobayashi, Masanori

AU - Shindo, Masaki

AU - Machida, Hirohisa

AU - Tanigawa, Tetsuya

AU - Yamagami, Hirokazu

AU - Watanabe, Kenji

AU - Watanabe, Toshio

AU - Tominaga, Kazunari

AU - Arakawa, Tetsuo

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N2 - Background and Objective: Insufficient absorption of proton pump inhibitor (PPI) might be a treatment refractory factor, however, limited evidences were reported on the effect of pharmacokinetic parameter of PPI when taking the drug after food intake. The aim of this study was to compare the pharmacokinetic parameter of lansoprazole orally dispersing (LPZ-OD) tablet between conditions of taking the drug after food intake and under fasting conditions. Methods: Nine healthy male volunteers took LPZ-OD (Takepron® OD) tablet 30 mg either 15 minutes after breakfast or under fasting conditions in a cross-over fashion. The wash-out period of each term was 7 days at least. Blood samples were taken for measurement of pharmacokinetic parameter of LPZ. Results: The AUC 0-inf, C max, and t max in the drug administration after food intake were significantly decreased than that of fasting conditions. The respective AUC 0-inf was 4512±1958 ng·h/mL and 3083±1688 ng·h/mL (p<0.05), C max was 1275±528 ng/mL and 624±307 ng/mL (p<0.05), and t max was 2.0±0.8 h and 3.3±1.0 h (p<0.05). No significant difference in t 1/2 was observed. Conclusions: This study suggested food intake may affect pharmacokinetic parameters (AUC 0-inf, C max, and t max) of LPZ-OD tablet.

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