The effect of oral administration of eicosapentaenoic and docosahexaenoic acids on acute inflammation and fatty acid composition in rats

N. Nakamura, T. Hamazaki, M. Kobayashi, Kazunaga Yazawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To investigate effects of eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) on acute inflammation, we fed rats either of the following four diets: an EPA-rich diet for 5 or 15 days, a DHA-rich diet for 5 or 15 days, a control diet for 5 or 15 days, and standard chow for 15 days. At the end of diets, the carrageenan-induced swelling of footpads was measured. Peritoneal cells were analyzed for their fatty acids in the phospholipid fraction. The swelling was similarly reduced in the EPA and DHA groups (p<0.05, if fed for 15 days) compared with rats fed the control diet for 15 days. The mean proportion of arachidonic acid (AA) to the sum of highly unsaturated fatty acids was correlated (r=0.87) to the mean degree of swelling among all dietary groups (n=7). Effects of EPA and DHA might be explained by the reduced availability of AA for eicosanoid formation represented by the proportion of AA.

Original languageEnglish
Pages (from-to)161-170
Number of pages10
JournalJournal of Nutritional Science and Vitaminology
Volume40
Issue number2
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Eicosapentaenoic Acid
Docosahexaenoic Acids
eicosapentaenoic acid
docosahexaenoic acid
oral administration
Oral Administration
Fatty Acids
inflammation
fatty acid composition
Diet
Inflammation
rats
arachidonic acid
Arachidonic Acid
diet
highly unsaturated fatty acids
eicosanoids
Eicosanoids
Carrageenan
carrageenan

Keywords

  • acute inflammation
  • arachidonic acid
  • carrageenan
  • docosahexaenoic acid
  • eicosapentaenoic acid
  • fatty acid composition
  • n-3 fatty acids
  • peritoneal cells

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

The effect of oral administration of eicosapentaenoic and docosahexaenoic acids on acute inflammation and fatty acid composition in rats. / Nakamura, N.; Hamazaki, T.; Kobayashi, M.; Yazawa, Kazunaga.

In: Journal of Nutritional Science and Vitaminology, Vol. 40, No. 2, 1994, p. 161-170.

Research output: Contribution to journalArticle

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