Abstract
Regular exercise has the capability of decreasing the incidence and progress of certain cancers. Murine sarcoma, (S-180) cells were transplanted to control (TC), exercise trained (10 week, 1 hour day, 5 times/ week) mice, which had the swimming training terminated at the time of transplantation (ETT), and also to a group of mice that continued to exercise during tumor bearing (ETC). Continuous exercise decreased the size of tumor by about 50%. The accumulation of reactive carbonyl groups (RCD), were not significantly different for any group. The oxidative modification of proteins in the liver of the animals decreased in the exercise- trained non-tumor bearing group compared with control or tumor-bearing groups. No significant alteration was detected in the level of mutant p53. The data indicate that regular exercise retards the development of sarcoma solid tumors and it seems unlikely that massive uncompensated oxidative stress takes place in the tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 93-96 |
| Number of pages | 4 |
| Journal | Journal of Sports Science and Medicine |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 2011 Mar 1 |
| Externally published | Yes |
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Keywords
- Cancer
- DNA damage
- Exercise
- Oxidative stress
- Reactive carbonyl derivatives
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
The effect of regular exercise on development of sarcoma tumor and oxidative damage in mice liver. / Sasvari, Maria; Taylor, Albert W.; Gaal, Dezso; Radak, Zsolt.
In: Journal of Sports Science and Medicine, Vol. 10, No. 1, 01.03.2011, p. 93-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of regular exercise on development of sarcoma tumor and oxidative damage in mice liver
AU - Sasvari, Maria
AU - Taylor, Albert W.
AU - Gaal, Dezso
AU - Radak, Zsolt
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Regular exercise has the capability of decreasing the incidence and progress of certain cancers. Murine sarcoma, (S-180) cells were transplanted to control (TC), exercise trained (10 week, 1 hour day, 5 times/ week) mice, which had the swimming training terminated at the time of transplantation (ETT), and also to a group of mice that continued to exercise during tumor bearing (ETC). Continuous exercise decreased the size of tumor by about 50%. The accumulation of reactive carbonyl groups (RCD), were not significantly different for any group. The oxidative modification of proteins in the liver of the animals decreased in the exercise- trained non-tumor bearing group compared with control or tumor-bearing groups. No significant alteration was detected in the level of mutant p53. The data indicate that regular exercise retards the development of sarcoma solid tumors and it seems unlikely that massive uncompensated oxidative stress takes place in the tumor.
AB - Regular exercise has the capability of decreasing the incidence and progress of certain cancers. Murine sarcoma, (S-180) cells were transplanted to control (TC), exercise trained (10 week, 1 hour day, 5 times/ week) mice, which had the swimming training terminated at the time of transplantation (ETT), and also to a group of mice that continued to exercise during tumor bearing (ETC). Continuous exercise decreased the size of tumor by about 50%. The accumulation of reactive carbonyl groups (RCD), were not significantly different for any group. The oxidative modification of proteins in the liver of the animals decreased in the exercise- trained non-tumor bearing group compared with control or tumor-bearing groups. No significant alteration was detected in the level of mutant p53. The data indicate that regular exercise retards the development of sarcoma solid tumors and it seems unlikely that massive uncompensated oxidative stress takes place in the tumor.
KW - Cancer
KW - DNA damage
KW - Exercise
KW - Oxidative stress
KW - Reactive carbonyl derivatives
UR - http://www.scopus.com/inward/record.url?scp=79952472749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952472749&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:79952472749
VL - 10
SP - 93
EP - 96
JO - Journal of Sports Science and Medicine
JF - Journal of Sports Science and Medicine
SN - 1303-2968
IS - 1
ER -