The effects of beta-hydroxy-beta-methylbutyrate-free acidsupplementation and resistance training on oxidative stress markers

A randomized,double-blind, placebo-controlled study

Hamid Arazi, Abbas Asadi, Katsuhiko Suzuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variablesin responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group (n = 8) or a placebo supplementation group (n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed.Following intervention, both the HMB-FA and placebo supplementation groups showed significant decreases in MDA (effect size [ES]; 0.39, 0.33) and PC (ES; 1.37,1.41), respectively. However,8-OHdG did not change after 6 weeks of training in any of the groups. In addition, both groups showed similar training effects on biochemical variables after 6 weeks of intervention. It was concluded that HMB-FA supplementation during resistance training did not add further adaptive changes related to oxidative stress markers.

Original languageEnglish
Article number76
JournalAntioxidants
Volume7
Issue number6
DOIs
Publication statusPublished - 2018 Jun 11

Fingerprint

Oxidative stress
Resistance Training
Oxidative Stress
Placebos
Acids
Malondialdehyde
Blood
Lymphocytes
Aspartate Aminotransferases
Alanine Transaminase
Alkaline Phosphatase
Monocytes
Proteins
Neutrophils
Leukocytes
Cells
Education
beta-hydroxyisovaleric acid

Keywords

  • Free radicals
  • Leucine
  • Oxidative stress
  • Strength training

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

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title = "The effects of beta-hydroxy-beta-methylbutyrate-free acidsupplementation and resistance training on oxidative stress markers: A randomized,double-blind, placebo-controlled study",
abstract = "The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variablesin responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group (n = 8) or a placebo supplementation group (n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed.Following intervention, both the HMB-FA and placebo supplementation groups showed significant decreases in MDA (effect size [ES]; 0.39, 0.33) and PC (ES; 1.37,1.41), respectively. However,8-OHdG did not change after 6 weeks of training in any of the groups. In addition, both groups showed similar training effects on biochemical variables after 6 weeks of intervention. It was concluded that HMB-FA supplementation during resistance training did not add further adaptive changes related to oxidative stress markers.",
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author = "Hamid Arazi and Abbas Asadi and Katsuhiko Suzuki",
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N2 - The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variablesin responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group (n = 8) or a placebo supplementation group (n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed.Following intervention, both the HMB-FA and placebo supplementation groups showed significant decreases in MDA (effect size [ES]; 0.39, 0.33) and PC (ES; 1.37,1.41), respectively. However,8-OHdG did not change after 6 weeks of training in any of the groups. In addition, both groups showed similar training effects on biochemical variables after 6 weeks of intervention. It was concluded that HMB-FA supplementation during resistance training did not add further adaptive changes related to oxidative stress markers.

AB - The aim of this study was to investigate the effects of 6-week beta-hydroxy-beta methylbutyrate-free acid (HMB-FA) supplementation on oxidative stress and biochemical variablesin responses to resistance training. Sixteen healthy young males participated in this study and were randomly assigned to a HMB-FA supplementation group (n = 8) or a placebo supplementation group (n = 8). The resistance training program was applied for 6 weeks with two sessions per week. Blood samples were collected before and after training, and 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyl (PC), and biochemical variables, such as alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and the numbers of total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were analyzed.Following intervention, both the HMB-FA and placebo supplementation groups showed significant decreases in MDA (effect size [ES]; 0.39, 0.33) and PC (ES; 1.37,1.41), respectively. However,8-OHdG did not change after 6 weeks of training in any of the groups. In addition, both groups showed similar training effects on biochemical variables after 6 weeks of intervention. It was concluded that HMB-FA supplementation during resistance training did not add further adaptive changes related to oxidative stress markers.

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