The effects of beverage intake after exhaustive exercise on organ damage, inflammation and oxidative stress in healthy males

Takaki Tominaga, Tsukasa Ikemura, Koichi Yada, Kazue Kanda, Kaoru Sugama, Sihui Ma, Wonjun Choi, Mayu Araya, Jiapeng Huang, Nobuhiro Nakamura, Katsuhiko Suzuki

Research output: Contribution to journalArticlepeer-review

Abstract

Strenuous exercise induces organ damage, inflammation and oxidative stress. To prevent exercise-induced organ damage, inflammation and oxidative stress, rehydrating may be an effective strategy. In the present study, we aimed to examine whether beverage intake after exhaustive exercise to recover from dehydration prevents such disorders. Thirteen male volunteers performed incremental cycling exercise until exhaustion. Immediately after exercise, the subjects drank an electrolyte containing water (rehydrate trial: REH) or did not drink any beverage (control trial: CON). Blood samples were collected before (Pre), immediately (Post), 1 h and 2 h after exercise. Urine samples were also collected before (Pre) and 2 h after exercise. We measured biomarkers of organ damage, inflammation and oxidative stress in blood and urine. Biomarkers of muscle, renal and intestinal damage and inflammation increased in the blood and urine after exercise. However, changes in biomarkers of organ damage and inflammation did not differ between trials (p > 0.05). The biomarker of oxidative stress, thiobarbituric acid reactive substances (TBARS), in plasma, showed different changes between trials (p = 0.027). One hour after exercise, plasma TBARS concentration in REH had a higher trend than that in CON (p = 0.052), but there were no significant differences between Pre and the other time points in each trial. These results suggest that beverage intake after exercise does not attenuate exercise-induced organ damage, inflammation or oxidative stress in healthy males. However, rehydration restores exercise-induced oxidative stress more quickly.

Original languageEnglish
Article number866
JournalAntioxidants
Volume10
Issue number6
DOIs
Publication statusPublished - 2021 Jun

Keywords

  • Acute exercise
  • Beverage intake
  • Endotoxin
  • Inflammation
  • Organ damage
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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