The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness

A randomized, double-blind, placebo-controlled trial

Kazuhiro Shimizu, Hironori Sato, Yoko Suga, Satoko Yamahira, Masamichi Toba, Koji Hamuro, Keiji Kakumoto, Noriyuki Kohda, Takao Akama, Ichiro Kono, Shinya Kuno

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The purpose of the study was to evaluate the effects of Lactobacillus pentosus strain b240 (b240) intake and appropriate physical training on salivary secretory immunoglobulin A secretion in elderly adults with low physical fitness. Elderly adults with low physical fitness (daily step count below 3,500 steps) were divided into 2 groups: a b240 intake + exercise group (b240 group) and a placebo intake + exercise group (placebo group). Each subject continued intake of b240 or placebo and moderate-intensity resistance exercise for 12 weeks. Before and 4, 8, and 12 weeks after the start of intervention, each subject underwent saliva sampling. Before and after intervention, physical fitness tests and step count were measured. Our results showed that secretory immunoglobulin A secretion in 57 subjects during the b240/placebo intake period was significantly greater in the b240 group than in the placebo group (p<0.05). There were no significant changes in physical fitness tests before and after intervention in the 2 groups. The daily amount of walking increased significantly after intervention in both groups (p<0.05). These results suggest that in elderly adults with low physical activity and fitness, intake of b240 with appropriate physical exercise elevate salivary secretory immunoglobulin A secretion.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume54
Issue number1
DOIs
Publication statusPublished - 2014 Jan

Fingerprint

Secretory Immunoglobulin A
Physical Fitness
Placebos
Exercise
Sampling
Exercise Test
Saliva
Walking
Lactobacillus pentosus

Keywords

  • Elderly
  • Lactobacillus pentosus
  • Low physical fitness
  • Mucosal immunity
  • Salivary SIgA

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness : A randomized, double-blind, placebo-controlled trial. / Shimizu, Kazuhiro; Sato, Hironori; Suga, Yoko; Yamahira, Satoko; Toba, Masamichi; Hamuro, Koji; Kakumoto, Keiji; Kohda, Noriyuki; Akama, Takao; Kono, Ichiro; Kuno, Shinya.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 54, No. 1, 01.2014, p. 61-66.

Research output: Contribution to journalArticle

Shimizu, Kazuhiro ; Sato, Hironori ; Suga, Yoko ; Yamahira, Satoko ; Toba, Masamichi ; Hamuro, Koji ; Kakumoto, Keiji ; Kohda, Noriyuki ; Akama, Takao ; Kono, Ichiro ; Kuno, Shinya. / The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness : A randomized, double-blind, placebo-controlled trial. In: Journal of Clinical Biochemistry and Nutrition. 2014 ; Vol. 54, No. 1. pp. 61-66.
@article{29df8ea178f340ad9129b4e61e8867b3,
title = "The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: A randomized, double-blind, placebo-controlled trial",
abstract = "The purpose of the study was to evaluate the effects of Lactobacillus pentosus strain b240 (b240) intake and appropriate physical training on salivary secretory immunoglobulin A secretion in elderly adults with low physical fitness. Elderly adults with low physical fitness (daily step count below 3,500 steps) were divided into 2 groups: a b240 intake + exercise group (b240 group) and a placebo intake + exercise group (placebo group). Each subject continued intake of b240 or placebo and moderate-intensity resistance exercise for 12 weeks. Before and 4, 8, and 12 weeks after the start of intervention, each subject underwent saliva sampling. Before and after intervention, physical fitness tests and step count were measured. Our results showed that secretory immunoglobulin A secretion in 57 subjects during the b240/placebo intake period was significantly greater in the b240 group than in the placebo group (p<0.05). There were no significant changes in physical fitness tests before and after intervention in the 2 groups. The daily amount of walking increased significantly after intervention in both groups (p<0.05). These results suggest that in elderly adults with low physical activity and fitness, intake of b240 with appropriate physical exercise elevate salivary secretory immunoglobulin A secretion.",
keywords = "Elderly, Lactobacillus pentosus, Low physical fitness, Mucosal immunity, Salivary SIgA",
author = "Kazuhiro Shimizu and Hironori Sato and Yoko Suga and Satoko Yamahira and Masamichi Toba and Koji Hamuro and Keiji Kakumoto and Noriyuki Kohda and Takao Akama and Ichiro Kono and Shinya Kuno",
year = "2014",
month = "1",
doi = "10.3164/jcbn.13-62",
language = "English",
volume = "54",
pages = "61--66",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "The Society for Free Radical Research Japan",
number = "1",

}

TY - JOUR

T1 - The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness

T2 - A randomized, double-blind, placebo-controlled trial

AU - Shimizu, Kazuhiro

AU - Sato, Hironori

AU - Suga, Yoko

AU - Yamahira, Satoko

AU - Toba, Masamichi

AU - Hamuro, Koji

AU - Kakumoto, Keiji

AU - Kohda, Noriyuki

AU - Akama, Takao

AU - Kono, Ichiro

AU - Kuno, Shinya

PY - 2014/1

Y1 - 2014/1

N2 - The purpose of the study was to evaluate the effects of Lactobacillus pentosus strain b240 (b240) intake and appropriate physical training on salivary secretory immunoglobulin A secretion in elderly adults with low physical fitness. Elderly adults with low physical fitness (daily step count below 3,500 steps) were divided into 2 groups: a b240 intake + exercise group (b240 group) and a placebo intake + exercise group (placebo group). Each subject continued intake of b240 or placebo and moderate-intensity resistance exercise for 12 weeks. Before and 4, 8, and 12 weeks after the start of intervention, each subject underwent saliva sampling. Before and after intervention, physical fitness tests and step count were measured. Our results showed that secretory immunoglobulin A secretion in 57 subjects during the b240/placebo intake period was significantly greater in the b240 group than in the placebo group (p<0.05). There were no significant changes in physical fitness tests before and after intervention in the 2 groups. The daily amount of walking increased significantly after intervention in both groups (p<0.05). These results suggest that in elderly adults with low physical activity and fitness, intake of b240 with appropriate physical exercise elevate salivary secretory immunoglobulin A secretion.

AB - The purpose of the study was to evaluate the effects of Lactobacillus pentosus strain b240 (b240) intake and appropriate physical training on salivary secretory immunoglobulin A secretion in elderly adults with low physical fitness. Elderly adults with low physical fitness (daily step count below 3,500 steps) were divided into 2 groups: a b240 intake + exercise group (b240 group) and a placebo intake + exercise group (placebo group). Each subject continued intake of b240 or placebo and moderate-intensity resistance exercise for 12 weeks. Before and 4, 8, and 12 weeks after the start of intervention, each subject underwent saliva sampling. Before and after intervention, physical fitness tests and step count were measured. Our results showed that secretory immunoglobulin A secretion in 57 subjects during the b240/placebo intake period was significantly greater in the b240 group than in the placebo group (p<0.05). There were no significant changes in physical fitness tests before and after intervention in the 2 groups. The daily amount of walking increased significantly after intervention in both groups (p<0.05). These results suggest that in elderly adults with low physical activity and fitness, intake of b240 with appropriate physical exercise elevate salivary secretory immunoglobulin A secretion.

KW - Elderly

KW - Lactobacillus pentosus

KW - Low physical fitness

KW - Mucosal immunity

KW - Salivary SIgA

UR - http://www.scopus.com/inward/record.url?scp=84891784528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891784528&partnerID=8YFLogxK

U2 - 10.3164/jcbn.13-62

DO - 10.3164/jcbn.13-62

M3 - Article

VL - 54

SP - 61

EP - 66

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 1

ER -