The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain

Helga Ogonovszky, István Berkes, Shuzo Kumagai, Takao Kaneko, Shoichi Tahara, Sataro Goto, Zsolt Radak

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

We have tested the hypothesis that training with moderate- (MT), strenuous- (ST), or over- (OT) load can cause alterations in memory, lipid peroxidation, protein oxidation, DNA damage, activity of 8-oxoG-DNA glycosylase (OGG1) and brain-derived neurotrophic factor (BDNF), in rat brain. Rat memory was assessed by a passive avoidance test and the ST and OT group demonstrated improved memory. The content of BDNF was increased only in the OT group. The oxidative damage of lipids and DNA, as measured by thiobarbituric acid reactive substances (TBARS), and 8-hydroxydeoxyguanosine (8-OHdG), did not change significantly with exercise. Similarly, the activity of DNA repair enzyme, 8-oxoguanine DNA glycosylase (OGG1), was not altered with exercise training. On the other hand, the content of reactive carbonyl derivatives (RCDs) decreased in all groups and the decrease reached significance levels in the ST and OT groups. The activity of the proteasome complex increased in the brain of OT. The findings of this study imply that over-training does not induce oxidative stress in the brain and does not cause loss of memory. The improved memory was associated with enhanced BDNF content.

Original languageEnglish
Pages (from-to)635-640
Number of pages6
JournalNeurochemistry International
Volume46
Issue number8
DOIs
Publication statusPublished - 2005 Jan 1
Externally publishedYes

Fingerprint

DNA Repair
Brain-Derived Neurotrophic Factor
Oxidative Stress
DNA Glycosylases
Brain
DNA Damage
DNA Repair Enzymes
Thiobarbituric Acid Reactive Substances
Memory Disorders
Proteasome Endopeptidase Complex
Lipid Peroxidation
Exercise
Lipids
Proteins

Keywords

  • Brain function
  • Exercise
  • Free radicals
  • Hormesis
  • Oxidative damage

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. / Ogonovszky, Helga; Berkes, István; Kumagai, Shuzo; Kaneko, Takao; Tahara, Shoichi; Goto, Sataro; Radak, Zsolt.

In: Neurochemistry International, Vol. 46, No. 8, 01.01.2005, p. 635-640.

Research output: Contribution to journalArticle

Ogonovszky, Helga ; Berkes, István ; Kumagai, Shuzo ; Kaneko, Takao ; Tahara, Shoichi ; Goto, Sataro ; Radak, Zsolt. / The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. In: Neurochemistry International. 2005 ; Vol. 46, No. 8. pp. 635-640.
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