The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain

Zsolt Radak, Anna Toldy, Zsofia Szabo, Savvas Siamilis, Csaba Nyakas, Gabriella Silye, Judit Jakus, Sataro Goto

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

In the current investigation we tested how swimming training (T) (8 week, 5 times/week, 2 h/day), and detraining (DT) affects brain functions and oxidative stress markers in rat brain. The free radical concentration, measured by electron paramagnetic resonance, decreased in brain of T and DT rats compared to controls (C). The level of brain-derived neurotrophic factor (BDNF) increased as a result of training, but decreased below the control level after 6 weeks of detraining. In addition, the concentration of nerve growth factor (NGF) also declined with DT. The passive avoidance test was used to assess the memory of rats, and training-induced improvement was observed but the enhancement disappeared with detraining. When the content of mitochondrial electron transport complexes, as a potent free radical generator, was evaluated by the blue native gel method, no significant alterations were observed. The repair of nuclear and mitochondrial 8-oxodeoxyguanosine, as measured by the activity of OGG1, showed no significant difference. Therefore, the results suggest that regular exercise training improves memory, decreases the level of reactive oxygen species, and increase the production of BDNF and NGF. On the other hand, it appears that the beneficial effects of training are reversible in the brain, since detraining down-regulates the neurotrophin level, and memory. It is suggested that exercise training is more likely to beneficially effect the production of reactive oxygen species and the related oxidative damage.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalNeurochemistry International
Volume49
Issue number4
DOIs
Publication statusPublished - 2006 Sep 1
Externally publishedYes

Fingerprint

Nerve Growth Factors
Oxidative Stress
Brain-Derived Neurotrophic Factor
Brain
Nerve Growth Factor
Free Radicals
Reactive Oxygen Species
Exercise
Electron Spin Resonance Spectroscopy
Electron Transport
Down-Regulation
Gels
Learning

Keywords

  • Brain-derived neurotrophic factor
  • Detraining
  • Exercise
  • Memory
  • Oxidative stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. / Radak, Zsolt; Toldy, Anna; Szabo, Zsofia; Siamilis, Savvas; Nyakas, Csaba; Silye, Gabriella; Jakus, Judit; Goto, Sataro.

In: Neurochemistry International, Vol. 49, No. 4, 01.09.2006, p. 387-392.

Research output: Contribution to journalArticle

Radak, Zsolt ; Toldy, Anna ; Szabo, Zsofia ; Siamilis, Savvas ; Nyakas, Csaba ; Silye, Gabriella ; Jakus, Judit ; Goto, Sataro. / The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. In: Neurochemistry International. 2006 ; Vol. 49, No. 4. pp. 387-392.
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