The enhanced 32P labeling of CDP-diacylglycerol in c-myc gene expressed human kidney cancer cells

Yoshinobu Kubota, Taro Shuin, Masahiro Yao, Hiroko Inoue, Tohru Yoshioka

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    10 Citations (Scopus)

    Abstract

    Correlation between c-myc gene expression and phosphatidylinositol (PI) metabolism was studied using seven human kidney cancer cell lines. We found that the exceptional incorporation of 32P into CDP-diacyl-glycerol (CDP-DG) was observed in only two cell lines, in which c-myc expression was increased among seven cell lines tested. In these two cell lines, PI was also labeled. The other five cell lines indicated the accumulation of radioactive PI, whereas CDP- DG was unlabeled.

    Original languageEnglish
    Pages (from-to)159-162
    Number of pages4
    JournalFEBS Letters
    Volume212
    Issue number1
    DOIs
    Publication statusPublished - 1987 Feb 9

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    Keywords

    • (Kidney cancer cell)
    • c-myc gene
    • CDP-diacylglycerol
    • Phosphatidylinositol metabolism

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

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