The evolutionary change of the genetic code as restricted by the anticodon and identity of transfer RNA

Takuya Ueda, Kimitsuna Watanabe

Research output: Contribution to journalArticle

6 Citations (Scopus)


The discovery of non-universal genetic codes in several mitochondria and nuclear systems during the past ten years has necessitated a reconsideration of the concept that the genetic code is universal and frozen, as was once believed. Here, the flexibility of the relationship between codons and amino acids is discussed on the basis of the distribution of non-universal genetic codes in various organisms insofar as has been observed to date. Judging from the result of recent investigations into tRNA identity, it would appear that the non-participation of the anticodon in recognition by aminoacyl-tRNA synthetase has significantly influenced the variability of codons.

Original languageEnglish
Pages (from-to)345-364
Number of pages20
JournalOrigins of Life and Evolution of the Biosphere
Issue number5-6
Publication statusPublished - 1993 Dec 1
Externally publishedYes


ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Space and Planetary Science

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