The first chemical synthesis of wortmannin by starting from hydrocortisone

Seiji Sato, Masahisa Nakada, Masakatsu Shibasaki

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The first chemical synthesis of wortmannin, a potent and specific inhibitor of PI 3-kinases, was achieved by starting from commercially available and optically pure hydrocortisone.

Original languageEnglish
Pages (from-to)6141-6144
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number34
DOIs
Publication statusPublished - 1996 Aug 19
Externally publishedYes

Fingerprint

Phosphatidylinositol 3-Kinases
Hydrocortisone
wortmannin

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

The first chemical synthesis of wortmannin by starting from hydrocortisone. / Sato, Seiji; Nakada, Masahisa; Shibasaki, Masakatsu.

In: Tetrahedron Letters, Vol. 37, No. 34, 19.08.1996, p. 6141-6144.

Research output: Contribution to journalArticle

Sato, Seiji ; Nakada, Masahisa ; Shibasaki, Masakatsu. / The first chemical synthesis of wortmannin by starting from hydrocortisone. In: Tetrahedron Letters. 1996 ; Vol. 37, No. 34. pp. 6141-6144.
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