The first chemical synthesis of wortmannin by starting from hydrocortisone

Seiji Sato, Masahisa Nakada, Masakatsu Shibasaki

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The first chemical synthesis of wortmannin, a potent and specific inhibitor of PI 3-kinases, was achieved by starting from commercially available and optically pure hydrocortisone.

Original languageEnglish
Pages (from-to)6141-6144
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number34
DOIs
Publication statusPublished - 1996 Aug 19

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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