The first total synthesis and structural determination of actinopyrone A

Seijiro Hosokawa; Kazuya Yokota; Keisuke Imamura; Yasuaki Suzuki; Masataka Kawarasaki; Kuniaki Tatsuta

doi:10.1016/j.tetlet.2006.05.028

The first total synthesis and structural determination of actinopyrone A

Seijiro Hosokawa, Kazuya Yokota, Keisuke Imamura, Yasuaki Suzuki, Masataka Kawarasaki, Kuniaki Tatsuta

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Actinopyrone A (1) has been synthesized by using our developed remote stereoinduction, Kocienski olefination, Horner-Wadsworth-Emmons olefination, and reductive de-conjugation of the vinylpyrone. A concise method of O-methylation to obtain the γ-pyrone has also been established.

Original language	English
Pages (from-to)	5415-5418
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2006.05.028
Publication status	Published - 2006 Jul 24

Keywords

4-Pyrone
Actinopyrone A
Reductive de-conjugation
Remote stereoinduction
Structural determination
Total synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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keywords = "4-Pyrone, Actinopyrone A, Reductive de-conjugation, Remote stereoinduction, Structural determination, Total synthesis",

author = "Seijiro Hosokawa and Kazuya Yokota and Keisuke Imamura and Yasuaki Suzuki and Masataka Kawarasaki and Kuniaki Tatsuta",

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T1 - The first total synthesis and structural determination of actinopyrone A

AU - Hosokawa, Seijiro

AU - Yokota, Kazuya

AU - Imamura, Keisuke

AU - Suzuki, Yasuaki

AU - Kawarasaki, Masataka

AU - Tatsuta, Kuniaki

PY - 2006/7/24

Y1 - 2006/7/24

N2 - Actinopyrone A (1) has been synthesized by using our developed remote stereoinduction, Kocienski olefination, Horner-Wadsworth-Emmons olefination, and reductive de-conjugation of the vinylpyrone. A concise method of O-methylation to obtain the γ-pyrone has also been established.

AB - Actinopyrone A (1) has been synthesized by using our developed remote stereoinduction, Kocienski olefination, Horner-Wadsworth-Emmons olefination, and reductive de-conjugation of the vinylpyrone. A concise method of O-methylation to obtain the γ-pyrone has also been established.

KW - 4-Pyrone

KW - Actinopyrone A

KW - Reductive de-conjugation

KW - Remote stereoinduction

KW - Structural determination

KW - Total synthesis

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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