The first total synthesis and structural determination of actinopyrone A

Seijiro Hosokawa, Kazuya Yokota, Keisuke Imamura, Yasuaki Suzuki, Masataka Kawarasaki, Kuniaki Tatsuta

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Actinopyrone A (1) has been synthesized by using our developed remote stereoinduction, Kocienski olefination, Horner-Wadsworth-Emmons olefination, and reductive de-conjugation of the vinylpyrone. A concise method of O-methylation to obtain the γ-pyrone has also been established.

Original languageEnglish
Pages (from-to)5415-5418
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number30
DOIs
Publication statusPublished - 2006 Jul 24

Keywords

  • 4-Pyrone
  • Actinopyrone A
  • Reductive de-conjugation
  • Remote stereoinduction
  • Structural determination
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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