Abstract
The first total synthesis and structural determination of (+)-BE-52440A have been achieved by enantiodivergent synthesis. S-Bridging dimerization including SN2 epoxy-opening reaction of tetrasubstituted epoxide 2 with sodium sulfide has been achieved in excellent yield with high regioselectivity. The structure of (+)-BE-52440A was determined to be the dimer of kalafungin type pyranonaphthoquinone.
Original language | English |
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Pages (from-to) | 8018-8021 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 48 |
Issue number | 45 |
DOIs | |
Publication status | Published - 2007 Nov 5 |
Keywords
- BE-52440A
- Dimerization
- Enantiodivergent synthesis
- Tetrasubstituted epoxide
- Total synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry