The first total synthesis and structural determination of lagunamycin

Seijiro Hosokawa, Shoichi Kuroda, Keisuke Imamura, Kuniaki Tatsuta

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    Lagunamycin (1) has been synthesized by using our developed remote stereoinduction, Knorr condensation, periodinane oxidation, and diazonation. This enantioselective synthesis determined the absolute configuration of lagunamycin. Existence of rotational conformers was confirmed by NMR studies.

    Original languageEnglish
    Pages (from-to)6183-6186
    Number of pages4
    JournalTetrahedron Letters
    Volume47
    Issue number35
    DOIs
    Publication statusPublished - 2006 Aug 28

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    Condensation
    Nuclear magnetic resonance
    Oxidation
    lagunamycin

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

    Cite this

    The first total synthesis and structural determination of lagunamycin. / Hosokawa, Seijiro; Kuroda, Shoichi; Imamura, Keisuke; Tatsuta, Kuniaki.

    In: Tetrahedron Letters, Vol. 47, No. 35, 28.08.2006, p. 6183-6186.

    Research output: Contribution to journalArticle

    Hosokawa, Seijiro ; Kuroda, Shoichi ; Imamura, Keisuke ; Tatsuta, Kuniaki. / The first total synthesis and structural determination of lagunamycin. In: Tetrahedron Letters. 2006 ; Vol. 47, No. 35. pp. 6183-6186.
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