The first total synthesis and structural determination of TMC-264

Kuniaki Tatsuta, Akiho Furuyama, Tomoe Yano, Yasuaki Suzuki, Takashi Ogura, Seijiro Hosokawa

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    The first total synthesis and structural determination of TMC-264 has been accomplished. Regioselective bromination, regioselective methoxymethylation, and nickel(0)-Lewis acid-mediated cyclization afforded multi-functionalized 1-methyl-dibenzo[b,d]-pyran skeleton.

    Original languageEnglish
    Pages (from-to)4036-4039
    Number of pages4
    JournalTetrahedron Letters
    Volume49
    Issue number25
    DOIs
    Publication statusPublished - 2008 Jun 16

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    Keywords

    • Absolute configuration
    • Antiallergic agent
    • Biaryl coupling
    • Regioselective methoxymethylation
    • TMC-264
    • Total synthesis

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Drug Discovery

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