The first total synthesis and structural determination of TMC-264

Kuniaki Tatsuta, Akiho Furuyama, Tomoe Yano, Yasuaki Suzuki, Takashi Ogura, Seijiro Hosokawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The first total synthesis and structural determination of TMC-264 has been accomplished. Regioselective bromination, regioselective methoxymethylation, and nickel(0)-Lewis acid-mediated cyclization afforded multi-functionalized 1-methyl-dibenzo[b,d]-pyran skeleton.

Original languageEnglish
Pages (from-to)4036-4039
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number25
DOIs
Publication statusPublished - 2008 Jun 16

Keywords

  • Absolute configuration
  • Antiallergic agent
  • Biaryl coupling
  • Regioselective methoxymethylation
  • TMC-264
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'The first total synthesis and structural determination of TMC-264'. Together they form a unique fingerprint.

  • Cite this